Pik3ca,b,d:Pik3r2 (Pi3k) binds p-Y799,Y1052,Y1172-Kdr in Pecam1:Cdh5:p-Y799,Y1052,Y1172-Kdr:p-Y1063,Y1230-Flt4:Ctnnb1

Stable Identifier
R-MMU-9860569
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Pik3ca,b,d:Pik3r2 (Pi3k) binds p-Y799,Y1052,Y1172-Kdr in Pecam1:Cdh5:p-Y799,Y1052,Y1172-Kdr:p-Y1063,Y1230-Flt4:Ctnnb1
Phosphoinositol 3-kinase (Pik3ca,b,d:Pik3r2, abbreviated as Pi3k) binds phosphorylated Kdr (Vegfr2) through an interaction between Pik3r2 (p85) of Pi3k and phosphorylated tyrosine-801 and tyrosine-1175 residues of Kdr (Dayanir et al. 2001, Tzima et al. 2005). Both Flt4 (Vegfr3) and Kdr bind Cdh5 (VE-cadherin) and are located in the same mechanosensory complex (inferred from human homologs). Flt4 plays an overlapping role with Kdr in activating PI3K by phosphorylation in response to shear stress (inferred from human homologs).
Literature References
PubMed ID Title Journal Year
16163360 A mechanosensory complex that mediates the endothelial cell response to fluid shear stress

Tzima, E, Irani-Tehrani, M, Kiosses, WB, Dejana, E, Schultz, DA, Engelhardt, B, Cao, G, DeLisser, H, Schwartz, MA

Nature 2005
11278468 Identification of tyrosine residues in vascular endothelial growth factor receptor-2/FLK-1 involved in activation of phosphatidylinositol 3-kinase and cell proliferation

Dayanir, V, Meyer, RD, Lashkari, K, Rahimi, N

J. Biol. Chem. 2001
Participants
Input
Output
Orthologous Events
PI3K binds p-Y801,Y1054,Y1175-KDR in p-Y713-PECAM1:CDH5:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 (Homo sapiens)
Authored
May, B  (2024-02-07)
Reviewed
Xiao, R  (2024-07-16)
Created
May, B  (2024-02-07)
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