p-Y397-PTK2 (FAK) phosphorylates CHUK (IKKA)

Stable Identifier
R-HSA-9861469
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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p-Y397-PTK2 (FAK) phosphorylates CHUK (IKKA)
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PTK2 (FAK) is activated by integrin signaling and phosphorylates CHUK (IKKA) to initiate NF-kB signaling during the response of endothelial cells to turbulent flow (Albarrán-Juárez et al. 2018). In the cytosol, phospho-CHUK phosphorylates inhibitors of NF-kB transcription factors (Régnier et al. 1997), resulting in the proteolysis of the inhibitors and transit of the NF-kB transcription factors to the nucleus where they activate pro-inflammatory genes and thereby promote atherosclerosis.
Literature References
PubMed ID Title Journal Year
25798060 Identification of novel focal adhesion kinase substrates: role for FAK in NFκB signaling

Gao, L, Gelman, IH, Dwyer, SF

Int J Biol Sci 2015
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Output
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Catalyst Activity

protein tyrosine kinase activity of p-Y397-PTK2 [cytosol]

Physical Entity
p-Y397-PTK2 [cytosol] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
p-Y397-PTK2 (FAK) phosphorylates CHUK (IKKA) (Bos taurus)
p-Y397-PTK2 (FAK) phosphorylates CHUK (IKKA) (Canis familiaris)
p-Y397-PTK2 (FAK) phosphorylates CHUK (IKKA) (Mus musculus)
p-Y397-PTK2 (FAK) phosphorylates CHUK (IKKA) (Rattus norvegicus)
Authored
May, B  (2024-02-16)
Reviewed
Xiao, R  (2024-07-16)
Created
May, B  (2024-02-21)
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