p-S26-ANXA2 binds integrin alpha5:beta1 at the plasma membrane

Stable Identifier
R-HSA-9865215
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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p-S26-ANXA2 binds integrin alpha5:beta1 at the plasma membrane
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Annexin A2 (ANXA2) dephosphorylated on tyrosine-24 binds the integrin alpha5 (ITGA5) subunit of the integrin alpha5:integrin beta1 (ITGA5:ITGB1) dimer (Zhang et al. 2020). ANXA2 also binds phospholipids of the plasma membrane in a calcium-dependent manner (Rescher et al. 2004). As a result of the ANXA2-integrin interaction, ITGA5:ITGB1 moves into lipid rafts enriched in cholesterol and phosphoinositol-4,5-bisphosphate (Zhang et al. 2020).
Literature References
PubMed ID Title Journal Year
15226372 Annexin 2 is a phosphatidylinositol (4,5)-bisphosphate binding protein recruited to actin assembly sites at cellular membranes

Rescher, U, Ruhe, D, Ludwig, C, Zobiack, N, Gerke, V

J Cell Sci 2004
32673515 Coupling of Integrin α5 to Annexin A2 by Flow Drives Endothelial Activation

Zhang, C, Zhou, T, Chen, Z, Yan, M, Li, B, Lv, H, Wang, C, Xiang, S, Shi, L, Zhu, Y, Ai, D

Circ Res 2020
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Orthologous Events
p-S26-ANXA2 binds integrin alpha5:beta1 at the plasma membrane (Bos taurus)
p-S26-ANXA2 binds integrin alpha5:beta1 at the plasma membrane (Caenorhabditis elegans)
p-S26-ANXA2 binds integrin alpha5:beta1 at the plasma membrane (Canis familiaris)
p-S26-ANXA2 binds integrin alpha5:beta1 at the plasma membrane (Danio rerio)
p-S26-ANXA2 binds integrin alpha5:beta1 at the plasma membrane (Drosophila melanogaster)
p-S26-ANXA2 binds integrin alpha5:beta1 at the plasma membrane (Gallus gallus)
p-S26-ANXA2 binds integrin alpha5:beta1 at the plasma membrane (Mus musculus)
p-S26-ANXA2 binds integrin alpha5:beta1 at the plasma membrane (Rattus norvegicus)
p-S26-ANXA2 binds integrin alpha5:beta1 at the plasma membrane (Sus scrofa)
p-S26-ANXA2 binds integrin alpha5:beta1 at the plasma membrane (Xenopus tropicalis)
Authored
May, B  (2024-03-07)
Reviewed
Xiao, R  (2024-07-16)
Created
May, B  (2024-03-09)
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