Pannexin-1 (PANX1) channel transports ATP from the cytosol to the extracellular region

Stable Identifier
R-HSA-9855161
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane, extracellular region
ReviewStatus
5/5
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Pannexin-1 (PANX1) channel transports ATP from the cytosol to the extracellular region
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The homoheptameric PANX1 (Pannexin-1) channel (Ruan et al. 2020, Zhang et al. 2021, Kuzuya et al. 2022) transports ATP from the cytosol to the extracellular region in response to mechanical stimuli such as membrane stretching (Bao et al. 2004). PANX1 channels are activated by calcium and also by extracellular ATP acting through the purinergic receptor P2RY2. Therefore, PANX1 may participate, through ATP-induced ATP release, in propagation of the intercellular calcium waves that are observed in response to mechanical stimulation (Locovei et al. 2006). Mechanical stimulation of PIEZO1 channels by laminar shear stress causes influx of calcium that activates release of ATP at least partly through PANX1 and possibly PANX2 channels (Wang et al. 2016).
Literature References
PubMed ID Title Journal Year
16364313 Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium

Locovei, S, Wang, J, Dahl, G

FEBS Lett 2006
15304325 Pannexin membrane channels are mechanosensitive conduits for ATP

Bao, L, Locovei, S, Dahl, G

FEBS Lett 2004
27797339 Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release

Wang, S, Chennupati, R, Kaur, H, Iring, A, Wettschureck, N, Offermanns, S

J Clin Invest 2016
Participants
Input
Output
Participates
as an event of
Catalyst Activity

monoatomic anion channel activity of PANX1 heptamer [plasma membrane]

Physical Entity
PANX1 heptamer [plasma membrane] (Homo sapiens)
Activity
monoatomic anion channel activity (GO:0005253)
This event is regulated
Positively by
Regulator
P2RY2:ATP [plasma membrane] (Homo sapiens)
Regulator
Ca2+ [cytosol]
Inferred From
Pannexin-1 (Panx1) channel transports ATP from the cytosol to the extracellular region (Mus musculus)
Cross References
RHEA
Authored
May, B  (2023-11-27)
Reviewed
Xiao, R  (2024-07-16)
Created
May, B  (2023-11-29)
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