PI3K binds p-Y801,Y1054,Y1175-KDR in p-Y713-PECAM1:CDH5:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1

Stable Identifier
R-HSA-9860477
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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PI3K binds p-Y801,Y1054,Y1175-KDR in p-Y713-PECAM1:CDH5:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1
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Phosphoinositol 3-kinase (PIK3CA,B,D:PIK3R2, abbreviated as PI3K) binds phosphorylated KDR (VEGFR2) through an interaction between PIK3R2 (p85) of PI3K and phosphorylated tyrosine-801 and tyrosine-1175 residues of KDR (inferred from mouse homologs). Both FLT4 (VEGFR3, a paralog of KDR) and KDR bind CDH5 (VE-cadherin) and are located in the same mechanosensory complex (Coon et al. 2015). FLT4 plays an overlapping role with KDR in activating PI3K by phosphorylation in response to shear stress (Coon et al. 2015).
Literature References
PubMed ID Title Journal Year
25800053 Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex

Yun, S, Han, J, Baeyens, N, Coon, BG, Ross, TD, Thomas, JL, Fang, JS, Schwartz, MA, Budatha, M

J Cell Biol 2015
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Output
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as an event of
Inferred From
Pik3ca,b,d:Pik3r2 (Pi3k) binds p-Y799,Y1052,Y1172-Kdr in Pecam1:Cdh5:p-Y799,Y1052,Y1172-Kdr:p-Y1063,Y1230-Flt4:Ctnnb1 (Mus musculus)
Authored
May, B  (2024-02-04)
Reviewed
Xiao, R  (2024-07-16)
Created
May, B  (2024-02-07)
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