Reactome | Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177

Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177

Stable Identifier

R-HSA-9860792

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177

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Phosphorylated AKT1 phosphorylates serine-1117 of NOS3 (eNOS) (Dimmeler et al. 1999, Jin et al. 2021, inferred from bovine homologs in Fulton et al. 1999) in response to laminar shear stress (Jin et al. 2021). Knockdown of AKT1 reduced phosphorylation of serine-1117 but not serine-1179 of NOS3, as serine-1179 is phosphorylated by PKN2 (Jin et al. 2021).

Literature References

PubMed ID	Title	Journal	Year
10376603	Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation Dimmeler, S, Fleming, I, Fisslthaler, B, Hermann, C, Busse, R, Zeiher, AM	Nature	1999
34499618	Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation Jin, YJ, Chennupati, R, Li, R, Liang, G, Wang, S, Iring, A, Graumann, J, Wettschureck, N, Offermanns, S	J Clin Invest	2021