Phospho-PI3K in p-Y713-PECAM1:CDH5:PIK3CA,B,D:p-Y464-PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 phosphorylates phosphoinositol-4,5-bisphosphate to yield phosphoinositol-3,4,5-trisphosphate

Stable Identifier
R-HSA-9860816
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Phospho-PI3K in p-Y713-PECAM1:CDH5:PIK3CA,B,D:p-Y464-PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 phosphorylates phosphoinositol-4,5-bisphosphate to yield phosphoinositol-3,4,5-trisphosphate
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Phosphorylated phosphatidylinositol 3-kinase (PI3K, PIK3CA,B,D:p-PIK3R2) associated with KDR during laminar shear stress phosphorylates phosphatidylinositol-4,5-bisphosphate to yield phosphatidylinositol-3,4,5-trisphosphate (inferred from mouse homologs).
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Input
Output
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as an event of
Catalyst Activity

1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of p-Y713-PECAM1:CDH5:PIK3CA,B,D:p-Y464-PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 [plasma membrane]

Physical Entity
p-Y713-PECAM1:CDH5:PIK3CA,B,D:p-Y464-PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 [plasma membrane] (Homo sapiens)
Activity
1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934)
Inferred From
Phospho-Pi3k in p-Pecam1:Cdh5:Pik3ca,b,d:p-Y458-Pik3r2:p-Y799,Y1052,Y1172-Kdr:p-Y1063,Y1230-Flt4:Ctnnb1 phosphorylates phosphatidylinositol-4,5-bisphosphate to yield phosphatidylinositol-3,4,5-trisphosphate (Mus musculus)
Cross References
RHEA
Authored
May, B  (2024-02-07)
Reviewed
Xiao, R  (2024-07-16)
Created
May, B  (2024-02-10)
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