Akt1 binds phosphoinositol-3,4,5-trisphosphate

Stable Identifier
R-MMU-9863573
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Akt1 binds phosphoinositol-3,4,5-trisphosphate
The Pleckstrin Homology (PH) domain of Akt1 (Pkb) binds phosphatidylinositol-3,4,5-trisphosphate at the plasma membrane (Frech et al. 1997).
Literature References
PubMed ID Title Journal Year
9079675 High affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of RAC/protein kinase B and their influence on kinase activity

Frech, M, Andjelkovic, M, Ingley, E, Reddy, KK, Falck, JR, Hemmings, BA

J. Biol. Chem. 1997
Participants
Input
Output
Orthologous Events
AKT1 binds phosphoinositol-3,4,5-trisphosphate (PIP3) (Homo sapiens)
Authored
May, B  (2024-03-02)
Reviewed
Xiao, R  (2024-07-16)
Created
May, B  (2024-03-04)
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