Integrin alpha5:integrin beta1 (ITGA5:ITGB1) binds fibronectin (FN1) matrix

Stable Identifier
R-BTA-9865179
Type
Reaction [binding]
Species
Bos taurus
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Integrin alpha5:integrin beta1 (ITGA5:ITGB1) binds fibronectin (FN1) matrix
The integrin alpha5:integrin beta1 (ITGA5:ITGB1) heterodimer is activated by a conformational change to expose the ligand-binding site of ITGA5, which binds fibronectin matrix (Yun et al. 2016).
Literature References
PubMed ID Title Journal Year
27595237 Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling

Yun, S, Budatha, M, Dahlman, JE, Coon, BG, Cameron, RT, Langer, R, Anderson, DG, Baillie, G, Schwartz, MA

Nat Cell Biol 2016
Participants
Input
Output
Orthologous Events
p-S26-ANXA2:integrin alpha5:integrin beta1 (p-S26-ANXA2:ITGA5:ITGB1) binds fibronectin (FN1) matrix (Homo sapiens)
Authored
May, B  (2024-03-09)
Reviewed
Xiao, R  (2024-07-16)
Created
May, B  (2024-03-09)
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