Integrin alpha5:integrin beta1 (ITGA5:ITGB1) binds fibronectin (FN1) matrix

Stable Identifier
R-BTA-9865179
Type
Reaction [binding]
Species
Bos taurus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Integrin alpha5:integrin beta1 (ITGA5:ITGB1) binds fibronectin (FN1) matrix
The integrin alpha5:integrin beta1 (ITGA5:ITGB1) heterodimer is activated by a conformational change to expose the ligand-binding site of ITGA5, which binds fibronectin matrix (Yun et al. 2016).
Literature References
PubMed ID Title Journal Year
27595237 Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling

Yun, S, Budatha, M, Dahlman, JE, Coon, BG, Cameron, RT, Langer, R, Anderson, DG, Baillie, G, Schwartz, MA

Nat Cell Biol 2016
Participants
Orthologous Events
Authored
Reviewed
Created
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