Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin)

Stable Identifier
R-HSA-9861485
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin)
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Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) activated by cytosolic calcium in response to laminar flow shear stress (Miyazaki et al. 2007) or turbulent flow shear stress (Miyazaki et al. 2010) cleaves the cytoskeletal protein Vinculin (VCL) at an unknown site to produce a 95 kDa fragment.
Literature References
Participants
Input
Output
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as an event of
Catalyst Activity

calcium-dependent cysteine-type endopeptidase activity of Calpain2:Ca2+ [plasma membrane]

Physical Entity
Calpain2:Ca2+ [plasma membrane] (Homo sapiens)
Activity
calcium-dependent cysteine-type endopeptidase activity (GO:0004198)
Orthologous Events
Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin) (Bos taurus)
Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin) (Canis familiaris)
Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin) (Danio rerio)
Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin) (Mus musculus)
Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin) (Rattus norvegicus)
Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin) (Sus scrofa)
Authored
May, B  (2024-02-16)
Reviewed
Xiao, R  (2024-07-16)
Created
May, B  (2024-02-21)
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