PDE4D5 in p-S26-ANXA2:PP2A:PDE4D5:ITGA5:ITGB1:fibronectin hydrolyzes cAMP to yield AMP

Stable Identifier
R-HSA-9865748
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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PDE4D5 in p-S26-ANXA2:PP2A:PDE4D5:ITGA5:ITGB1:fibronectin hydrolyzes cAMP to yield AMP
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As assayed by the activation of CREB by cAMP, PDE4D5, in a complex with integrins and fibronectin (PDE4D5:ITGA5:ITGB1:fibronectin), hydrolyzes cAMP to yield AMP and hence reduces activation of CREB (inferred from bovine homologs). Cyclic AMP acting via PKA is anti-inflammatory (Funk et al. 2010), therefore PDE4D5 acts to increase inflammation.
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Catalyst Activity

3',5'-cyclic-AMP phosphodiesterase activity of p-S26-ANXA2:PP2A:PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane]

Physical Entity
p-S26-ANXA2:PP2A:PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
Activity
3',5'-cyclic-AMP phosphodiesterase activity (GO:0004115)
Inferred From
PDE4D in PDE4D:ITGA5:ITGB1:fibronectin hydrolyzes cAMP to yield AMP (Bos taurus)
Cross References
Rhea
Authored
May, B  (2024-03-18)
Reviewed
Xiao, R  (2024-07-16)
Created
May, B  (2024-03-18)
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