Reactome | Phosphorylation of STAT1 on tyrosine-701 is enhanced by p-S172-IKBKE

Phosphorylation of STAT1 on tyrosine-701 is enhanced by p-S172-IKBKE

Stable Identifier

R-HSA-9865511

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Phosphorylation of STAT1 on tyrosine-701 is enhanced by p-S172-IKBKE

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Phosphorylated IKBKE (IKKepsilon) positively regulates the phosphorylation of STAT1 on tyrosine-701 in response to low shear flow stress (Zhu et al. 2020, Lv et al. 2024). IKBKE is a serine kinase (Tenoever et al. 2007) rather than a tyrosine kinase, therefore the effect of IKBKE on tyrosine phosphorylation of STAT1 is probably indirect.

Literature References

PubMed ID	Title	Journal	Year
32037480	Low shear stress damages endothelial function through STAT1 in endothelial cells (ECs) Zhu, L, Wang, F, Yang, H, Zhang, J, Chen, S	J Physiol Biochem	2020
38315275	Low-Shear Stress Promotes Atherosclerosis via Inducing Endothelial Cell Pyroptosis Mediated by IKKε/STAT1/NLRP3 Pathway Lv, Y, Jiang, Z, Zhou, W, Yang, H, Jin, G, Wang, D, Kong, C, Qian, Z, Gu, Y, Chen, S, Zhu, L	Inflammation	2024