Reactome | p-Y393-ABL1 phosphorylates tyrosine-407 of YAP1

p-Y393-ABL1 phosphorylates tyrosine-407 of YAP1

Stable Identifier

R-HSA-9865196

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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p-Y393-ABL1 phosphorylates tyrosine-407 of YAP1

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During turbulent flow across endothelial cells, ABL1 is activated by phosphorylation of tyrosine-393 (tyrosine-412 of isoform 2) and then phosphorylates YAP1 on tyrosine-407 (Levy et al. 2008, Li et al. 2019). Phosphorylation of YAP1 requires engagement of integrin alpha5 (ITGA5) with fibronectin (Li et al. 2019).

Literature References

PubMed ID	Title	Journal	Year
18280240	Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage Levy, D, Adamovich, Y, Reuven, N, Shaul, Y	Mol. Cell	2008
30629551	c-Abl regulates YAPY357 phosphorylation to activate endothelial atherogenic responses to disturbed flow Li, B, He, J, Lv, H, Liu, Y, Lv, X, Zhang, C, Zhu, Y, Ai, D	J Clin Invest	2019