Phosphorylation of PI3K in p-Y713-PECAM1:CDH5:PIK3CA,B,D:PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1

Stable Identifier
R-HSA-9860571
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Phosphorylation of PI3K in p-Y713-PECAM1:CDH5:PIK3CA,B,D:PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1
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After binding phosphorylated KDR (VEGFR2), phosphoinositol 3-kinase (PI3K, PIK3CA,B,D:PIK3R2) is phosphorylated on tyrosine-458 of the regulatory subunit PIK3R2 (p85) (inferred from mouse homologs). A SRC family kinase acts upstream of the phosphorylation of PI3K and may phosphorylate PI3K directly (inferred from mouse homologs).
Literature References
PubMed ID Title Journal Year
25800053 Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex

Coon, BG, Baeyens, N, Han, J, Budatha, M, Ross, TD, Fang, JS, Yun, S, Thomas, JL, Schwartz, MA

J Cell Biol 2015
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Output
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Inferred From
Phosphorylation of Pi3k in Pecam1:Cdh5:PiK3ca,b,d:Pik3r2:p-799,Y1052,Y1172-Kdr:p-Y1063,Y1230-Flt4:Ctnnb1 (Mus musculus)
Authored
May, B  (2024-02-07)
Reviewed
Xiao, R  (2024-07-16)
Created
May, B  (2024-02-07)
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