PPP2R2A binds p-S585-PDE4D:ITGA5:ITGB1:fibronectin

Stable Identifier
R-BTA-9865863
Type
Reaction [binding]
Species
Bos taurus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PPP2R2A binds p-S585-PDE4D:ITGA5:ITGB1:fibronectin
PPP2R2A (B55α), a regulatory subunit of the PP2A phosphatase complex, binds the N-terminal domain of the phosphodiesterase PDE4D in a complex with integrin alpha5 and integrin beta1 (ITGA5:ITGB1) bound to fibronectin matrix (Yun et al. 2016).
Literature References
PubMed ID Title Journal Year
31408443 Integrin α5β1 regulates PP2A complex assembly through PDE4D in atherosclerosis

Yun, S, Hu, R, Schwaemmle, ME, Scherer, AN, Zhuang, Z, Koleske, AJ, Pallas, DC, Schwartz, MA

J Clin Invest 2019
Participants
Input
Output
Orthologous Events
PPP2R2A binds p-S715-PDE4D5 in p-S26-ANXA2:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin (Homo sapiens)
Authored
May, B  (2024-03-20)
Reviewed
Xiao, R  (2024-07-16)
Created
May, B  (2024-03-20)
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