Calpain2 cleaves Tln1 (Talin-1)

Stable Identifier
R-MMU-9855152
Type
Reaction [transition]
Species
Mus musculus
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Calpain2 cleaves Tln1 (Talin-1)
Calpain2 (m-Calpain) cleaves Tln1 (Talin-1, Talin) between amino acid residues 433 and 434 (Franco et al. 2004, Saxena et al. 2017).
Literature References
PubMed ID Title Journal Year
15302585 Isoform specific function of calpain 2 in regulating membrane protrusion

Franco, S, Perrin, B, Huttenlocher, A

Exp Cell Res 2004
15448700 Calpain-mediated proteolysis of talin regulates adhesion dynamics

Franco, SJ, Rodgers, MA, Perrin, BJ, Han, J, Bennin, DA, Critchley, DR, Huttenlocher, A

Nat Cell Biol 2004
29052994 Force-Induced Calpain Cleavage of Talin Is Critical for Growth, Adhesion Development, and Rigidity Sensing

Saxena, M, Changede, R, Hone, J, Wolfenson, H, Sheetz, MP

Nano Lett 2017
Participants
Input
Output
Catalyst Activity

calcium-dependent cysteine-type endopeptidase activity of Calpain2 [plasma membrane]

Physical Entity
Calpain2 [plasma membrane] (Mus musculus)
Activity
calcium-dependent cysteine-type endopeptidase activity (GO:0004198)
Orthologous Events
Calpain2 (m-Calpain) cleaves TLN1 (Talin-1) (Homo sapiens)
Authored
May, B  (2023-11-27)
Reviewed
Xiao, R  (2024-07-16)
Created
May, B  (2023-11-29)
Cite Us!