ADM:CALCRL:RAMP2:G-alpha(s):GTP:G-beta:G-gamma dissociates

Stable Identifier
R-HSA-9861293
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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ADM:CALCRL:RAMP2:G-alpha(s):GTP:G-beta:G-gamma dissociates
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After binding GTP, G-alpha(s) dissociates from the G-beta:G-gamma subcomplex (Inoue et al. 2019, Ahn et al. 2023) and binds adenylate cyclase, thereby activating production of cAMP.
Literature References
PubMed ID Title Journal Year
37128611 Gαs slow conformational transition upon GTP binding and a novel Gαs regulator

Ahn, D, Provasi, D, Duc, NM, Xu, J, Salas-Estrada, L, Spasic, A, Yun, MW, Kang, J, Gim, D, Lee, J, Du, Y, Filizola, M, Chung, KY

iScience 2023
31160049 Illuminating G-Protein-Coupling Selectivity of GPCRs

Inoue, A, Raimondi, F, Kadji, FMN, Singh, G, Kishi, T, Uwamizu, A, Ono, Y, Shinjo, Y, Ishida, S, Arang, N, Kawakami, K, Gutkind, JS, Aoki, J, Russell, RB

Cell 2019
Participants
Input
Output
Participates
as an event of
Authored
May, B  (2024-02-12)
Reviewed
Xiao, R  (2024-07-16)
Created
May, B  (2024-02-16)
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