ADM:CALCRL:RAMP2:G-alpha(s):GDP:G-beta:G-gamma exchanges GDP for GTP

Stable Identifier
R-HSA-9861324
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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ADM:CALCRL:RAMP2:G-alpha(s):GDP:G-beta:G-gamma exchanges GDP for GTP
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The G-alpha(s) subunit in a complex with G-beta:G-gamma and the Adrenomedullin receptor complex (ADM:CALCRL:RAMP2) (Weston et al. 2016, Woolley et al. 2017) releases GDP, which is replaced by GTP due to the high GTP:GDP ratio in cells (Echeverria et al. 2000, Brito et al. 2002, Jeong and Chung 2023)
Literature References
PubMed ID Title Journal Year
10649434 Mutagenesis in the switch IV of the helical domain of the human Gsalpha reduces its GDP/GTP exchange rate

Torrejón, M, Olate, J, Toro, MJ, Echeverria, V, Ropero, S, Hinrichs, MV, Martinez, J

J Cell Biochem 2000
27566546 Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors

Woodlock, DA, Reynolds, CA, Hodgson, R, Weston, C, Poyner, DR, Dowell, SJ, Shah, A, Watkins, HA, Winfield, I, Ladds, G, Mobarec, JC, Harris, M

J Biol Chem 2016
11968001 S111N mutation in the helical domain of human Gs(alpha) reduces its GDP/GTP exchange rate

Olate, J, Romo, X, Brito, M, Hinrichs, MV, Guzmán, L, Soto, X

J Cell Biochem 2002
36835474 Structural and Functional Implication of Natural Variants of Gαs

Chung, KY, Jeong, Y

Int J Mol Sci 2023
28705698 Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs

Hay, DL, Reynolds, CA, Poyner, DR, Conner, AC, Simms, J, Woolley, MJ, Garelja, ML, Walker, CS, Mobarec, JC

Biochem Pharmacol 2017
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Output
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Orthologous Events
ADM:CALCRL:RAMP2:G-alpha(s):GDP:G-beta:G-gamma exchanges GDP for GTP (Bos taurus)
ADM:CALCRL:RAMP2:G-alpha(s):GDP:G-beta:G-gamma exchanges GDP for GTP (Canis familiaris)
ADM:CALCRL:RAMP2:G-alpha(s):GDP:G-beta:G-gamma exchanges GDP for GTP (Mus musculus)
ADM:CALCRL:RAMP2:G-alpha(s):GDP:G-beta:G-gamma exchanges GDP for GTP (Rattus norvegicus)
ADM:CALCRL:RAMP2:G-alpha(s):GDP:G-beta:G-gamma exchanges GDP for GTP (Sus scrofa)
Authored
May, B  (2024-02-12)
Reviewed
Xiao, R  (2024-07-16)
Created
May, B  (2024-02-16)
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