p-Y701-STAT1 binds the NLRP3 gene

Stable Identifier
R-HSA-9865524
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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p-Y701-STAT1 binds the NLRP3 gene
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Phosphorylated STAT1 binds two sites in the NLRP3 promoter: one site is 750-764 bp upstream and the other site is 832-842 bp upstream of the transcription start site (Lv et al. 2024). Phosphorylated STAT1 enhances expression of NLRP3, a sensory subunit of the NLRP3 inflammasome complex that regulates secretion of cytokines (reviewed in Kodi et al. 2024).
Literature References
PubMed ID Title Journal Year
38315275 Low-Shear Stress Promotes Atherosclerosis via Inducing Endothelial Cell Pyroptosis Mediated by IKKε/STAT1/NLRP3 Pathway

Lv, Y, Jiang, Z, Zhou, W, Yang, H, Jin, G, Wang, D, Kong, C, Qian, Z, Gu, Y, Chen, S, Zhu, L

Inflammation 2024
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Output
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Authored
May, B  (2024-03-09)
Reviewed
Xiao, R  (2024-07-16)
Created
May, B  (2024-03-13)
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