Reactome | Ub-443-UBC(381-456) [cytosol]

6P5B, 6V5D, 4LCD, 4UN2, 3VUW, 2KDF, 2K8B, 2DEN, 6N6R, 6OI4, 2N2K, 7EAO, 4KSK, 2MBQ, 4WZP, 4NQK, 3AUL, 1YX6, 3O65, 7K6Q, 6TXB, 8E7O, 1XD3, 3B0A, 5AF6, 1XQQ, 2JZZ, 4DDG, 4BOS, 5AF5, 3VUX, 8ST8, 8A9K, 6WKR, 4AP4, 7M4N, 5A5B, 7M4O, 2KLG, 5C7M, 6B7O, 5WQ4, 2IBI, 2PEA, 4K7S, 6VAF, 3C0R, 4MM3, 1Q5W, 3PT2, 6NQA, 5UDH, 3ZNZ, 6VEN, 1FXT, 2FUH, 7K6P, 3VFK, 3UGB, 2L3Z, 6SQR, 2ZVO, 2HTH, 2NR2, 5ZQ6, 2MRE, 2GBM, 3HM3, 3V6E, 5NMC, 7R70, 3PTF, 2MCN, 2KX0, 2J7Q, 3B08, 1SIF, 2GBN, 7JXV, 3EHV, 2MBO, 2KJH, 2MOR, 4K7U, 3MTN, 7TV4, 3MHS, 2JRI, 5B83, 3N3K, 2GMI, 3IFW, 3RUL, 8PMQ, 2LD9, 3OFI, 6N13, 2GBK, 6TNF, 1D3Z, 5E6J, 8B3I, 2GBJ, 5ZQ7, 2LVQ, 2RU6, 8EB0, 2LVO, 8A9J, 2K6D, 7M4M, 3BY4, 3V6C, 3H7S, 3Q3F, 1NBF, 6VAE, 4DHZ, 2G45, 7NPI, 1S1Q, 6T9L, 7BXG, 6WJD, 5C7J, 3LDZ, 6B7M, 7MYF, 7UV5, 3ONS, 4ZQS, 3I3T, 3WXF, 8PJN, 8ADB, 4BOZ, 1TBE, 2Y5B, 4V3L, 3NS8, 5AIU, 2LVP, 3JSV, 7ZJ3, 8FTQ, 5ZQ5, 3ZNH, 1F9J, 1G6J, 6RYA, 5OXH, 5ZQ4, 2JF5, 2ZVN, 3A33, 6W9S, 4AUQ, 8AMS, 3PRM, 2WDT, 6UPU, 4IG7, 6TUV, 3N32, 2XEW, 3ALB, 4DHJ, 2Z59, 6A43, 2ZCB, 2MWS, 8R5H, 8Q7R, 7EB9, 1UBI, 4MSQ, 8RX0, 6UMP, 1UD7, 6TTU, 5AIT, 2W9N, 3KW5, 5OXI, 3H7P, 6UMS, 3K9O, 3EFU, 1C3T, 2PE9, 3ZLZ, 3K9P, 3KVF, 3ZNI, 4IUM, 2BGF, 5ZQ3, 2K8C, 4FJV, 4LDT, 6A44, 3DVN, 2RR9, 4HXD, 7MIC, 6S53, 5OHV, 3N30, 4V3K, 6W9D, 1CMX, 3U30, 4XOL, 8EAZ, 4XOK, 2MI8, 2OJR, 7B5N, 2AYO, 6W9R, 6T7F, 4HK2, 3EEC, 8T48, 4BVU, 1UBQ, 6QML, 4K1R, 7BBF, 4MDK, 7YUI, 2KN5, 6WTG, 8ST9, 8SVF, 4I6N, 2KHW, 8OFF, 2LZ6, 5H07, 1OGW, 3DVG, 2K25, 4I6L, 6Z7V, 7MEX, 7B5L, 6AQR, 4MSM, 5OE7, 3WXE, 4JQW, 6NXK, 3TMP, 4K7W, 3VUY, 8ST7, 2MJ5, 7BBD, 6K2U, 7EAL, 3IHP, 7UYH, 1ZGU, 8PQL, 3JW0, 4KSL, 5NLI, 6EQI, 5NLF, 7OWD, 6Q00, 2JY6, 1YX5, 3OJ3, 4DDI, 7B5M, 6KBE, 5NL4, 3OJ4, 3JVZ, 2GBR, 5AF4, 6ULH, 1GJZ, 7KEO, 2O6V

Interactors (76)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.96	15
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.851	7
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.84	8
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.821	6
UniProt:Q13501 SQSTM1	7	SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) SQSTM1 [nucleoplasm] (R-HSA-210961) SQSTM1 [cytosol] (R-HSA-193937)	0.806	5
UniProt:Q04206 RELA	7	MeK310-RELA [nucleoplasm] (R-HSA-8865233) p-S536-RELA [nucleoplasm] (R-HSA-9861499) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.77	6
UniProt:Q92783 STAM	1	STAM [cytosol] (R-HSA-182925)	0.766	6
UniProt:Q9Y6K9 IKBKG	12	IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) K63polyUb-IKBKG [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.75	4
UniProt:P40343 VPS27			0.715	5
UniProt:Q86VP1 TAX1BP1	1	TAX1BP1 [cytosol] (R-HSA-937346)	0.715	8
UniProt:P54252-1 ATXN3			0.704	4
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955)	0.702	3
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.688	5
UniProt:P54727 RAD23B	2	RAD23B [nucleoplasm] (R-HSA-62590) RAD23B [cytosol] (R-HSA-8850589)	0.683	5
UniProt:Q96B97 SH3KBP1	3	SH3KBP1 [plasma membrane] (R-HSA-182955) SH3KBP1 [cytosol] (R-HSA-182957) Ub-SH3KBP1 [cytosol] (R-HSA-182926)	0.683	6
UniProt:Q9Y253 POLH	2	MonoUb-K682,K686,K694,K709-POLH [nucleoplasm] (R-HSA-5655163) POLH [nucleoplasm] (R-HSA-110287)	0.658	4
UniProt:O43583 DENR			0.656	3
UniProt:P25963 NFKBIA	9	PolyUb-NFKBIA [cytosol] (R-HSA-6782960) NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA [nucleoplasm] (R-HSA-4656929) monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805)	0.656	3
UniProt:O43318 MAP3K7	10	PolyUb-MAP3K7 [cytosol] (R-HSA-6782968) MAP3K7 [plasma membrane] (R-HSA-9012677) K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (R-HSA-5607649) K63polyUb-34,158-TAK1 [cytosol] (R-HSA-5607643) p-MAP3K7 [cytosol] (R-HSA-168163) p-T187-MAP3K7 [cytosol] (R-HSA-206014) MAP3K7 [endosome membrane] (R-HSA-450315) p-T184,T187-MAP3K7 [endosome membrane] (R-HSA-450332) MAP3K7 [cytosol] (R-HSA-168156) p-T184,T187-MAP3K7 [cytosol] (R-HSA-202527)	0.656	4
UniProt:Q14596 NBR1	2	NBR1 [peroxisomal membrane] (R-HSA-9665177) NBR1 [cytosol] (R-HSA-9665180)	0.636	3
UniProt:Q16186 ADRM1	2	ADRM1 [nucleoplasm] (R-HSA-9918361) ADRM1 [cytosol] (R-HSA-5665939)	0.609	11
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.602	3
UniProt:P98170 XIAP	3	XIAP [nucleoplasm] (R-HSA-3322366) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [cytosol] (R-HSA-50849)	0.602	3
UniProt:Q9UBN7 HDAC6	4	HDAC6 [nucleoplasm] (R-HSA-351589) HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [lysosomal lumen] (R-HSA-9660002)	0.593	3
UniProt:Q99PZ6 OSPG			0.591	3
UniProt:Q14934 NFAC4			0.591	3
UniProt:Q8TAT6 NPLOC4	2	NPLOC4 [nucleoplasm] (R-HSA-5654987) NPLOC4 [cytosol] (R-HSA-9755492)	0.59	2
UniProt:P35226 BMI1	3	BMI1 [nucleoplasm] (R-HSA-389121) p-S-BMI1 [nucleoplasm] (R-HSA-3229116) monoSUMO1-K88-BMI1 [nucleoplasm] (R-HSA-4551729)	0.589	2
UniProt:Q9UER7 DAXX	13	monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX S138* [nucleoplasm] (R-HSA-9673081) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A36Qfs*108 [nucleoplasm] (R-HSA-9673105) DAXX [nucleoplasm] (R-HSA-3222068)	0.573	2
UniProt:P0DTD1-PRO_0000449621 REP			0.558	2
UniProt:P0C6X7-PRO_0000037311 REP			0.558	3
ChEBI:167176 GRL-0617			0.558	4
UniProt:Q64339	3	Isg15 [nucleoplasm] (R-MMU-5653665) Isg15 [nucleoplasm] (R-MMU-5653745) Isg15 [cytosol] (R-MMU-936552)	0.558	2
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.558	2
UniProt:Q05086-3 UBE3A			0.556	3
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	3
UniProt:Q9NRQ2 PLS4			0.556	3
UniProt:Q96CS7 PKHB2			0.556	3
UniProt:Q15038 DAZP2			0.556	6
UniProt:P60604 UBE2G2	2	Ub-C89-UBE2G2 [cytosol] (R-HSA-8864195) UBE2G2 [cytosol] (R-HSA-947640)	0.556	3
UniProt:Q92567-2 FAM168A			0.556	3
UniProt:Q8N3F0 MTURN			0.556	3
UniProt:Q9BSL1 UBAC1	1	UBAC1 [cytosol] (R-HSA-8851644)	0.556	3
UniProt:O95208-2 EPN2			0.556	3
UniProt:Q9H305 CDIP1			0.556	3
UniProt:Q5VVQ6 YOD1	1	YOD1 [cytosol] (R-HSA-6781909)	0.556	3
UniProt:Q6ICB0 DESI1			0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P05412 JUN	4	p-S63,S73-JUN [cytosol] (R-HSA-8868682) JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194)	0.547	2
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.547	2
UniProt:O76080 ZFAN5			0.544	3
UniProt:Q62921	1	RBCK1 [cytosol] (R-RNO-976018)	0.544	2
UniProt:Q12518	1	ENT1 [cytosol] (R-SCE-8865826-2)	0.544	3
UniProt:P06239 LCK	4	p-Y394-LCK [plasma membrane] (R-HSA-8857940) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [cytosol] (R-HSA-202308) LCK [cytosol] (R-HSA-167609)	0.544	2
UniProt:Q9Z2V5 Hdac6	3	HDAC6 [nucleoplasm] (R-MMU-351589) Hdac6 [cytosol] (R-MMU-9646357) HDAC6 [cytosol] (R-MMU-5324660)	0.544	2
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.544	2
UniProt:Q9UNA4 POLI	1	POLI [nucleoplasm] (R-HSA-5656133)	0.527	4
UniProt:Q8IXI1 RHOT2	1	RHOT2 [mitochondrial outer membrane] (R-HSA-3006730)	0.527	2
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) NEDD8(77-81) [cytosol] (R-HSA-6782654) NEDD8(1-81) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8 [cytosol] (R-HSA-416969) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.527	2
UniProt:Q9NX47 MARH5			0.524	2
UniProt:Q9H4L4 SENP3	1	SENP3 [nucleoplasm] (R-HSA-2984296)	0.524	2
UniProt:Q9ULH1 ASAP1	1	ASAP1 [cytosol] (R-HSA-5620905)	0.524	2
UniProt:P48357-3 LEPR			0.524	2
UniProt:Q9Y6R4 M3K4			0.524	2
UniProt:O43150 ASAP2			0.524	2
UniProt:Q9HB09-1 BCL2L12			0.524	3
UniProt:P04325 REV			0.524	2
UniProt:P09874 PARP1	4	polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) PARP1 [nucleoplasm] (R-HSA-201568)	0.524	2
UniProt:Q13887 KLF5	1	KLF5 [nucleoplasm] (R-HSA-381279)	0.524	2
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754)