Reactome | LCK [cytosol]

LCK [cytosol]

Stable Identifier

R-HSA-167609

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Lymphocyte specific tyrosine kinase

Icon

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - PI3K/AKT Signaling in Cancer (Homo sapiens)
    - Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
      - PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
        
        PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        CD28:PI3K [plasma membrane] (Homo sapiens)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
        
        FYN,LCK [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        CD28:PI3K [plasma membrane] (Homo sapiens)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
        
        FYN,LCK [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
  - Signaling by KIT in disease (Homo sapiens)
    - Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants (Homo sapiens)
      - Dimerization of STATs downstream of KIT mutants (Homo sapiens)
        
        p-JAK2:SFKs:p-KIT mutants:p-STAT dimers [plasma membrane] (Homo sapiens)
        
        KIT mutant dimers:SFKs [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
        
        p-JAK2:SFKs:p-KIT mutants:p-STATs [plasma membrane] (Homo sapiens)
        
        KIT mutant dimers:SFKs [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
      - Disassociation and translocation of STATs to the nucleus downstream of KIT mutants (Homo sapiens)
        
        KIT mutant dimers:SFKs:p-JAK2 [plasma membrane] (Homo sapiens)
        
        KIT mutant dimers:SFKs [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
        
        p-JAK2:SFKs:p-KIT mutants:p-STAT dimers [plasma membrane] (Homo sapiens)
        
        KIT mutant dimers:SFKs [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
      - JAK2 binds to p-KIT mutants (Homo sapiens)
        
        KIT mutant dimers:SFKs [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
        
        KIT mutant dimers:SFKs:JAK2 [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
      - KIT mutants bind SFKs (Homo sapiens)
        
        KIT mutant dimers:SFKs [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
      - Phosphorylation of JAK2 downstream of KIT mutants (Homo sapiens)
        
        KIT mutant dimers:SFKs:JAK2 [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
        
        KIT mutant dimers:SFKs:p-JAK2 [plasma membrane] (Homo sapiens)
        
        KIT mutant dimers:SFKs [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
      - Phosphorylation of STATs downstream of KIT mutants (Homo sapiens)
        
        KIT mutant dimers:SFKs:p-JAK2:STATs [plasma membrane] (Homo sapiens)
        
        KIT mutant dimers:SFKs:p-JAK2 [plasma membrane] (Homo sapiens)
        
        KIT mutant dimers:SFKs [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
        
        p-JAK2:SFKs:p-KIT mutants:p-STATs [plasma membrane] (Homo sapiens)
        
        KIT mutant dimers:SFKs [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
      - Recruitment of STATs by KIT mutants (Homo sapiens)
        
        KIT mutant dimers:SFKs:p-JAK2 [plasma membrane] (Homo sapiens)
        
        KIT mutant dimers:SFKs [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
        
        KIT mutant dimers:SFKs:p-JAK2:STATs [plasma membrane] (Homo sapiens)
        
        KIT mutant dimers:SFKs:p-JAK2 [plasma membrane] (Homo sapiens)
        
        KIT mutant dimers:SFKs [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HIV Infection (Homo sapiens)
      - Host Interactions of HIV factors (Homo sapiens)
        
        The role of Nef in HIV-1 replication and disease pathogenesis (Homo sapiens)
        
        Nef and signal transduction (Homo sapiens)
        
        Nef Binds and activates the Src-family tyrosine kinase Lck (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
        
        Lck:Nef [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
        
        Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters (Homo sapiens)
        
        Nef Mediated CD4 Down-regulation (Homo sapiens)
        
        Nef mediated disruption of CD4:Lck Complex (Homo sapiens)
        
        CD4:Lck Complex [plasma membrane] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - Negative regulation of the PI3K/AKT network (Homo sapiens)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
        
        PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        CD28:PI3K [plasma membrane] (Homo sapiens)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
        
        FYN,LCK [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
    - PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
      - Activator:PI3K [plasma membrane] (Homo sapiens)
        
        CD28:PI3K [plasma membrane] (Homo sapiens)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
        
        FYN,LCK [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by SCF-KIT (Homo sapiens)
    - Dimerization of STATs (Homo sapiens)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
    - Disassociation and translocation of STATs to the nucleus (Homo sapiens)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
    - GRB2 is indirectly recruited to p-KIT through SHP2 (Homo sapiens)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
      - p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
    - Indirect recruitment of GAB2 to p-KIT (Homo sapiens)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
    - Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Homo sapiens)
      - PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
    - Interaction of Src family kinases with p-KIT (Homo sapiens)
      - SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
      - Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
    - JAK2 binds to p-KIT (Homo sapiens)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
      - SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
    - Phosphorylation and activation of VAV1 (Homo sapiens)
      - SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
      - Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
    - Phosphorylation of GAB2 by SFKs (Homo sapiens)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
      - Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
    - Phosphorylation of JAK2 (Homo sapiens)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
    - Phosphorylation of SHP2 by SFKs (Homo sapiens)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
      - Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
      - p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
    - Phosphorylation of STATs (Homo sapiens)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
    - Phosphorylation of p-KIT on Y900 by Src kinases (Homo sapiens)
      - SFKs:p-8Y-KIT:sSCF dimer:p-8Y-KIT [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
      - SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
      - Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
    - Recruitment of STATs (Homo sapiens)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
    - Regulation of KIT signaling (Homo sapiens)
      - Interaction of APS and p-KIT (Homo sapiens)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
      - Phosphorylation of APS (Homo sapiens)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
      - Recruitment of CBL to KIT (Homo sapiens)
        
        CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Homo sapiens)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Homo sapiens)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Homo sapiens)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
    - SHP2 interacts with p-KIT (Homo sapiens)
      - SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
    - Synthesis of PIP3 from PIP2 by PI3K (Homo sapiens)
      - PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase cycle (Homo sapiens)
      - RHOH GTPase cycle (Homo sapiens)
        
        RHOH binds effectors at the plasma membrane (Homo sapiens)
        
        RHOH effectors [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)
        
        RHOH:GTP:RHOH effectors [plasma membrane] (Homo sapiens)
        
        RHOH effectors [cytosol] (Homo sapiens)
        
        LCK [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P06239 LCK

Gene Names

LCK

Chain

initiator methionine:, chain:2-509

Reference Genes

BioGPS Gene:3932 LCK

COSMIC (genes):LCK LCK

CTD Gene:3932 LCK

dbSNP Gene:3932 LCK

ENSEMBL:ENSG00000182866 LCK

ENSEMBL_homo_sapiens_GENE:ENSG00000182866.18 LCK

HGNC:6524 LCK

KEGG Gene (Homo sapiens):3932 LCK

Monarch:3932 LCK

NCBI Gene:3932 LCK

OMIM:153390 LCK

UCSC:P06239 LCK

Reference Transcript

Other Identifiers

11740979_x_at

11752568_a_at

11752569_x_at

11755231_a_at

11756006_x_at

16662052

204890_PM_s_at

204890_s_at

204891_3p_s_at

204891_PM_s_at

204891_s_at

2059_s_at

2328842

2328843

2328845

2328847

2328848

2328850

2328852

2328853

2328854

2328855

2328856

2328857

2328859

2328860

2328863

2328864

2328865

2328866

2328867

33238_at

3932

7899753

A_23_P103361

A_33_P3382746

GE59664

GO:0000166

GO:0000242

GO:0001772

GO:0001784

GO:0002376

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0004722

GO:0005102

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005737

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0006468

GO:0006882

GO:0006919

GO:0007155

GO:0007169

GO:0009410

GO:0012501

GO:0016004

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0016787

GO:0018108

GO:0019901

GO:0019903

GO:0023052

GO:0030097

GO:0030154

GO:0030168

GO:0030217

GO:0031234

GO:0031295

GO:0034116

GO:0035556

GO:0036211

GO:0038083

GO:0038094

GO:0042060

GO:0042169

GO:0042608

GO:0042609

GO:0042610

GO:0042802

GO:0043226

GO:0043274

GO:0043548

GO:0045087

GO:0045121

GO:0048856

GO:0048870

GO:0050852

GO:0050853

GO:0050862

GO:0050870

GO:0050900

GO:0051117

GO:0051209

GO:0051249

GO:0055065

GO:0055085

GO:0070062

GO:0098542

GO:0098772

GO:0140096

GO:1903039

GO:2001244

HMNXSV003005783

ILMN_2277426

ILMN_2279844

ILMN_2377109

PH_hs_0000240

TC01000426.hg

U23852_s_at

g460965_3p_s_at

g4885448_3p_at

g4885448_3p_s_at

Participates

as a member of

as a component of

as an input of

as an output of

Nef mediated disruption of CD4:Lck Complex (Homo sapiens)

as a candidate of

SHC kinases in IL2 signaling [cytosol] (Homo sapiens)

Other forms of this molecule

p-Y394-LCK [plasma membrane]

p-Y505-LCK [plasma membrane]

p-Y394-LCK [cytosol]

Inferred To

LCK [cytosol] (Bos taurus)

LCK [cytosol] (Caenorhabditis elegans)

LCK [cytosol] (Canis familiaris)

LCK [cytosol] (Danio rerio)

LCK [cytosol] (Drosophila melanogaster)

LCK [cytosol] (Gallus gallus)

LCK [cytosol] (Mus musculus)

LCK [cytosol] (Rattus norvegicus)

LCK [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_005347.3, NP_001036236.1

ZINC - World Drugs

LCK_HUMAN

Guide to Pharmacology - Targets

2053

OpenTargets

ENSG00000182866

ZINC - FDA approved

LCK_HUMAN

ZINC - Substances

LCK_HUMAN

ZINC target

P06239

ZINC - Biogenic

LCK_HUMAN

PRO

P06239

PDB

4C3F, 1LCK, 3B2W, 3BYM, 1Q69, 3BYO, 3AC5, 1QPD, 2OF4, 2ZM1, 3LCK, 1Q68, 1CWE, 3AC4, 3AC3, 2OF2, 2OG8, 2OFV, 3ACJ, 1X27, 1BHH, 3ACK, 3AC2, 3AC1, 2IIM, 1QPJ, 1BHF, 1FBZ, 6H6A, 3AD5, 2PL0, 2ZYB, 1LKL, 3AC8, 3AD6, 2ZM4, 5MTM, 1LKK, 5MTN, 1QPE, 1LCJ, 1CWD, 3BRH, 1QPC, 3BYS, 3KXZ, 1KIK, 3BYU, 4D8K, 3MPM, 2OFU, 8X2P, 1H92, 3KMM, 3AD4, 6PDJ, 1IJR

ZINC - Investigational

LCK_HUMAN

ZINC - Metabolites

LCK_HUMAN

GeneCards

P06239

HPA

ENSG00000182866-LCK

Ensembl

ENSP00000328213, ENSP00000337825, ENST00000333070, ENST00000336890, ENSG00000182866

Pharos - Targets

P06239

ZINC - Predictions - Purchasable

LCK_HUMAN

Orphanet

20432

HMDB Protein

HMDBP01356

Interactors (40)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08575 PTPRC	2	PTPRC [secretory granule membrane] (R-HSA-6806150) PTPRC [plasma membrane] (R-HSA-197931)	0.851	7
UniProt:Q07666 KHDRBS1	3	p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995) KHDRBS1 [nucleoplasm] (R-HSA-8848941)	0.835	5
UniProt:P22575 TIP			0.815	9
UniProt:Q9Y2R2 PTPN22	1	PTPN22 [cytosol] (R-HSA-8852205)	0.783	6
UniProt:Q9NP31 SH2D2A	1	SH2D2A [cytosol] (R-HSA-4420125)	0.77	12
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637)	0.75	4
UniProt:P43405 SYK	6	p-Y-SYK [cytosol] (R-HSA-9705732) p-Y-SYK [plasma membrane] (R-HSA-429432) SYK [plasma membrane] (R-HSA-139844) p-6Y-SYK [cytosol] (R-HSA-1861712) p-Y348-SYK [cytosol] (R-HSA-437953) SYK [cytosol] (R-HSA-58268)	0.748	8
UniProt:P06239 LCK	4	p-Y394-LCK [plasma membrane] (R-HSA-8857940) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [cytosol] (R-HSA-202308) LCK [cytosol] (R-HSA-167609)	0.719	5
UniProt:P43403 ZAP70	3	ZAP70 [cytosol] (R-HSA-202397) p-Y493-ZAP70 [cytosol] (R-HSA-202368) p-Y315,Y493-ZAP70 [cytosol] (R-HSA-202252)	0.702	3
UniProt:P01730 CD4	4	CD4 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869082) CD4 [early endosome] (R-HSA-182147) CD4 [endoplasmic reticulum membrane] (R-HSA-180575) CD4 [plasma membrane] (R-HSA-167542)	0.702	3
UniProt:Q9H204 MED28	1	MED28 [nucleoplasm] (R-HSA-6804546)	0.691	4
UniProt:Q13444 ADAM15	1	ADAM15 [plasma membrane] (R-HSA-708329)	0.667	4
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.641	4
UniProt:Q12959 DLG1	4	DLG1 [endoplasmic reticulum membrane] (R-HSA-9610593) DLG1 [transport vesicle membrane] (R-HSA-9610631) DLG1 [cytosol] (R-HSA-416332) DLG1 [plasma membrane] (R-HSA-375977)	0.628	3
UniProt:P29350 PTPN6	5	PTPN6 [tertiary granule lumen] (R-HSA-6800952) PTPN6 [extracellular region] (R-HSA-6806315) PTPN6 [specific granule lumen] (R-HSA-6799641) PTPN6 [nucleoplasm] (R-HSA-9008911) PTPN6 [cytosol] (R-HSA-197938)	0.623	5
UniProt:P20963 CD247			0.609	2
UniProt:P08921	1	Cd2 [plasma membrane] (R-RNO-197795)	0.602	11
UniProt:O14672 ADAM10	6	ADAM10(215-824) [plasma membrane] (R-HSA-179885) ADAM10 [plasma membrane] (R-HSA-157237) ADAM10 [endoplasmic reticulum lumen] (R-HSA-8956768) p-ADAM10 [endoplasmic reticulum lumen] (R-HSA-8956999) ADAM10 [tertiary granule membrane] (R-HSA-6800992) ADAM10 [specific granule membrane] (R-HSA-6799566)	0.602	3
UniProt:P20749 BCL3			0.591	3
UniProt:Q13094 LCP2	2	p-Y113,128,145-LCP2 [cytosol] (R-HSA-202175) LCP2 [cytosol] (R-HSA-202306)	0.564	2
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.564	3
IntAct:EBI-7111687 TIP			0.558	2
UniProt:P23771 GATA3	2	GATA3 [nucleoplasm] (R-HSA-996768) PolyUb-GATA3 [nucleoplasm] (R-HSA-6783009)	0.556	3
UniProt:Q5VV42 CDKAL1	1	CDKAL1 [endoplasmic reticulum membrane] (R-HSA-6786612)	0.556	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:O60880 SH2D1A	1	SH2D1A [cytosol] (R-HSA-5685108)	0.547	2
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.544	2
UniProt:Q63767	4	phospho-Bcar1 [cytosol] (R-RNO-372645) phospho-Bcar1 [cytosol] (R-RNO-5218739) phospho-Bcar1 [cytosol] (R-RNO-8848723) Bcar1 [cytosol] (R-RNO-201625)	0.532	3
UniProt:P07947 YES1	2	MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411) YES1 [cytosol] (R-HSA-373640)	0.527	3
UniProt:P07948 LYN	7	MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728) LYN [plasma membrane] (R-HSA-197943) p-Y397-LYN [cytosol] (R-HSA-8942608) p-Y397-LYN [plasma membrane] (R-HSA-2454229) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) LYN [cytosol] (R-HSA-354251)	0.527	2
UniProt:Q8N1K5-1 THEMIS			0.525	3
UniProt:O43561 LAT	3	p-Y200,Y220-LAT [plasma membrane] (R-HSA-434829) LAT [plasma membrane] (R-HSA-202322) p-5Y-LAT [plasma membrane] (R-HSA-202364)	0.525	2
UniProt:Q13283 G3BP1	1	G3BP1 [cytosol] (R-HSA-9729517)	0.524	2
UniProt:P28482 MAPK1	18	MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293) MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185-MAPK1 [cytosol] (R-HSA-9635773) MAPK1 [nucleoplasm] (R-HSA-199960) MAPK1 [cytosol] (R-HSA-59282) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354)	0.524	2
UniProt:Q04759 PRKCQ	9	PRKCQ [photoreceptor disc membrane] (R-HSA-2648997) p-Y90,T219,T538,S676,S695-PRKCQ [plasma membrane] (R-HSA-2685606) PRKCQ(1-354) [cytosol] (R-HSA-212526) PRKCQ(355-706) [cytosol] (R-HSA-212514) PRKCQ [cytosol] (R-HSA-58216) PRKQC closed conformation [cytosol] (R-HSA-202185) PRKCQ [plasma membrane] (R-HSA-202346) p-Y90-PRKCQ [plasma membrane] (R-HSA-202395) p-Y90,T538,S676,S695-PRKCQ [plasma membrane] (R-HSA-202152)	0.499	2
UniProt:P40763-2 STAT3			0.488	2
UniProt:O60496 DOK2	1	DOK2 [cytosol] (R-HSA-204823)	0.488	2
UniProt:P32577	2	CSK [plasma membrane] (R-RNO-180499) CSK [cytosol] (R-RNO-203776)	0.482	2
UniProt:P04150 NR3C1	3	SUMO1-K277,K293-NR3C1 [nucleoplasm] (R-HSA-4341106) NR3C1 [cytosol] (R-HSA-5618118) NR3C1 [nucleoplasm] (R-HSA-879837)	0.463	3
UniProt:Q8TDQ0 HAVCR2	1	HAVCR2 [plasma membrane] (R-HSA-5340408)	0.462	2

Cite Us!