Reactome | p-4Y-CSF3R [endocytic vesicle membrane]

p-4Y-CSF3R [endocytic vesicle membrane]

Stable Identifier

R-HSA-9705736

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endocytic vesicle membrane

Synonyms

Granulocyte colony-stimulating factor receptor, CSF3R_HUMAN

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by CSF3 (G-CSF) (Homo sapiens)
    - Inactivation of CSF3 (G-CSF) signaling (Homo sapiens)
      - SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Homo sapiens)
        
        SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane] (Homo sapiens)
        
        SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Homo sapiens)
        
        CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Homo sapiens)
        
        CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Homo sapiens)
        
        CSF3 dimer:p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Homo sapiens)
        
        p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Homo sapiens)
        
        p-4Y-CSF3R [endocytic vesicle membrane] (Homo sapiens)
        
        p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Homo sapiens)
        
        p-4Y-CSF3R [endocytic vesicle membrane] (Homo sapiens)
      - SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 (Homo sapiens)
        
        SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Homo sapiens)
        
        CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Homo sapiens)
        
        CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Homo sapiens)
        
        CSF3 dimer:p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Homo sapiens)
        
        p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Homo sapiens)
        
        p-4Y-CSF3R [endocytic vesicle membrane] (Homo sapiens)
        
        p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Homo sapiens)
        
        p-4Y-CSF3R [endocytic vesicle membrane] (Homo sapiens)
        
        SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane] (Homo sapiens)
        
        SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Homo sapiens)
        
        CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Homo sapiens)
        
        CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Homo sapiens)
        
        CSF3 dimer:p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Homo sapiens)
        
        p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Homo sapiens)
        
        p-4Y-CSF3R [endocytic vesicle membrane] (Homo sapiens)
        
        p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Homo sapiens)
        
        p-4Y-CSF3R [endocytic vesicle membrane] (Homo sapiens)
      - SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed (Homo sapiens)
        
        SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Homo sapiens)
        
        CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Homo sapiens)
        
        CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Homo sapiens)
        
        CSF3 dimer:p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Homo sapiens)
        
        p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Homo sapiens)
        
        p-4Y-CSF3R [endocytic vesicle membrane] (Homo sapiens)
        
        p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Homo sapiens)
        
        p-4Y-CSF3R [endocytic vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99062 CSF3R

Gene Names

CSF3R, GCSFR

Chain

signal peptide:1-24, chain:25-836

Reference Genes

BioGPS Gene:1441 CSF3R

COSMIC (genes):CSF3R CSF3R

CTD Gene:1441 CSF3R

dbSNP Gene:1441 CSF3R

ENSEMBL:ENSG00000119535 CSF3R

ENSEMBL_homo_sapiens_GENE:ENSG00000119535.20 CSF3R

HGNC:2439 CSF3R

KEGG Gene (Homo sapiens):1441 CSF3R

Monarch:1441 CSF3R

NCBI Gene:1441 CSF3R

OMIM:138971 CSF3R

UCSC:Q99062 CSF3R

Reference Transcript

Other Identifiers

11740932_a_at

11756441_x_at

1441

1553297_PM_a_at

1553297_a_at

16685295

203591_PM_s_at

203591_s_at

2406784

2406785

2406786

2406787

2406788

2406789

2406790

2406791

2406792

2406793

2406794

2406797

2406798

2406801

2406803

2406804

2406805

2406806

2406807

2406808

2406809

2406810

2406811

2406813

2406814

2406816

2406821

2406822

2406825

2406826

34223_at

596_s_at

7914950

A_23_P126218

A_33_P3881262

GE57995

GO:0002376

GO:0004896

GO:0005515

GO:0005576

GO:0005764

GO:0005765

GO:0005773

GO:0005886

GO:0006952

GO:0007155

GO:0007165

GO:0009897

GO:0016020

GO:0019221

GO:0019955

GO:0023052

GO:0030154

GO:0030593

GO:0030666

GO:0031410

GO:0038023

GO:0043226

GO:0043235

GO:0045637

GO:0048856

GO:0048870

GO:0051916

GO:0060089

GO:0097186

HMNXSV003028812

Hs2.2175.4.S1_3p_s_at

ILMN_2323172

ILMN_2371280

M59820_at

PH_hs_0024334

TC01002512.hg

g4503080_3p_a_at

Participates

as a component of

p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Homo sapiens)

Other forms of this molecule

K48polyUb-K655,p-4Y-CSF3R [lysosomal membrane]

CSF3R [plasma membrane]

p-4Y-CSF3R [plasma membrane]

K48polyUb-K655,p-4Y-CSF3R [endocytic vesicle membrane]

Inferred To

phospho-csf3r [endocytic vesicle membrane] (Xenopus tropicalis)

Ghost homologue of p-4Y-CSF3R [endocytic vesicle membrane] (Drosophila melanogaster)

Ghost homologue of p-4Y-CSF3R [endocytic vesicle membrane] (Mus musculus)

Ghost homologue of p-4Y-CSF3R [endocytic vesicle membrane] (Rattus norvegicus)

phospho-p-4Y-CSF3R [endocytic vesicle membrane] (Gallus gallus)

phospho-CSF3R [endocytic vesicle membrane] (Bos taurus)

phospho-CSF3R [endocytic vesicle membrane] (Canis familiaris)

phospho-CSF3R [endocytic vesicle membrane] (Sus scrofa)

Modified Residues

Name

O4'-phospho-L-tyrosine at 727

Coordinate

727

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 752

Coordinate

752

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 767

Coordinate

767

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 787

Coordinate

787

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_000751.1, XP_016855859.1, NP_758519.1, XP_011539050.1, NP_724781.1

Guide to Pharmacology - Targets

1719

OpenTargets

ENSG00000119535

HPA

ENSG00000119535-CSF3R

GeneCards

Q99062

Ensembl

ENST00000373103, ENSP00000362198, ENSG00000119535, ENST00000373104, ENSP00000362196, ENST00000373106, ENSP00000362195

ZINC target

Q99062

PRO

Q99062

Pharos - Targets

Q99062

Orphanet

17340

PDB

2D9Q

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.524	2
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.462	4