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NPLOC4 [nucleoplasm]
Stable Identifier
R-HSA-5654987
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Nuclear protein localization protein 4 homolog, NPL4
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Damage Bypass (Homo sapiens)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Homo sapiens)
Translesion Synthesis by POLH (Homo sapiens)
SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Homo sapiens)
NPLOC4:UFD1L:VCP [nucleoplasm] (Homo sapiens)
NPLOC4 [nucleoplasm] (Homo sapiens)
NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Homo sapiens)
NPLOC4:UFD1L:VCP [nucleoplasm] (Homo sapiens)
NPLOC4 [nucleoplasm] (Homo sapiens)
SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Homo sapiens)
NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Homo sapiens)
NPLOC4:UFD1L:VCP [nucleoplasm] (Homo sapiens)
NPLOC4 [nucleoplasm] (Homo sapiens)
NPLOC4:UFD1L:VPC:SPRTN:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-Template DNA [nucleoplasm] (Homo sapiens)
NPLOC4:UFD1L:VCP [nucleoplasm] (Homo sapiens)
NPLOC4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8TAT6 NPLOC4
Gene Names
NPLOC4, KIAA1499, NPL4
Chain
initiator methionine:1, chain:2-608
Reference Genes
BioGPS Gene:55666 NPLOC4
COSMIC (genes):NPLOC4 NPLOC4
CTD Gene:55666 NPLOC4
dbSNP Gene:55666 NPLOC4
ENSEMBL:ENSG00000182446 NPLOC4
ENSEMBL:ENSG00000182446.15 NPLOC4
HGNC:18261 NPLOC4
KEGG Gene (Homo sapiens):55666 NPLOC4
Monarch:55666 NPLOC4
NCBI Gene:55666 NPLOC4
OMIM:606590 NPLOC4
UCSC:Q8TAT6 NPLOC4
Reference Transcript
RefSeq:XM_011524979.1 NPLOC4
RefSeq:NM_017921.3 NPLOC4
Other Identifiers
11733893_a_at
11755047_a_at
11755406_x_at
11761364_a_at
16849882
217796_PM_s_at
217796_s_at
3774030
3774031
3774032
3774033
3774034
3774035
3774036
3774037
3774038
3774039
3774040
3774042
3774043
3774045
3774059
3774060
3774063
3774064
3774066
3774074
3774075
3774077
3774079
3774084
3774085
3774087
3774090
3774095
55666
61951_at
65788_at
8019211
90976_at
A_23_P72044
A_33_P3238966
GE55586
GO:0002376
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005783
GO:0005829
GO:0006511
GO:0006886
GO:0007030
GO:0023052
GO:0030163
GO:0030433
GO:0030970
GO:0031625
GO:0032480
GO:0034098
GO:0036435
GO:0036501
GO:0039536
GO:0042175
GO:0043130
GO:0043161
GO:0043226
GO:0044877
GO:0046872
GO:0051117
GO:0070530
GO:0098542
HMNXSV003026832
ILMN_1807600
PH_hs_0023960
TC17001954.hg
g8923608_3p_a_at
Participates
as a component of
NPLOC4:UFD1L:VCP [nucleoplasm] (Homo sapiens)
Other forms of this molecule
NPLOC4 [cytosol]
Inferred To
zgc:55988 [nucleoplasm]
(Danio rerio)
NPLOC4 [nucleoplasm]
(Bos taurus)
NPLOC4 [nucleoplasm]
(Canis familiaris)
NPLOC4 [nucleoplasm]
(Gallus gallus)
NPLOC4 [nucleoplasm]
(Plasmodium falciparum)
NPLOC4 [nucleoplasm]
(Sus scrofa)
Nploc4 [nucleoplasm]
(Mus musculus)
Nploc4 [nucleoplasm]
(Rattus norvegicus)
Npl4 [nucleoplasm]
(Drosophila melanogaster)
npl-4.2 [nucleoplasm]
(Caenorhabditis elegans)
npl4 [nucleoplasm]
(Schizosaccharomyces pombe)
nploc4 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_060391.2
,
XP_011523281.1
OpenTargets
ENSG00000182446
HPA
ENSG00000182446-NPLOC4
GeneCards
Q8TAT6
Ensembl
ENSG00000182446
,
ENSP00000331487
,
ENST00000374747
,
ENST00000331134
,
ENSP00000363879
PRO
Q8TAT6
Pharos - Targets
Q8TAT6
PDB
7WWP
,
7WWQ
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P55072 VCP
8
Me3K315-VCP [cytosol]
(R-HSA-8932209)
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [extracellular region]
(R-HSA-6806191)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [cytosol]
(R-HSA-1181251)
0.848
9
UniProt:P37173 TGFBR2
9
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 K128Afs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 K128Sfs*35 [cytosol]
(R-HSA-3642166)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 [plasma membrane]
(R-HSA-170842)
0.556
3
UniProt:O94888 UBXN7
2
UBXN7 [cytosol]
(R-HSA-8956071)
ub-UBXN7 [cytosol]
(R-HSA-9755305)
0.499
5
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