Reactome | CNOT2 [cytosol]

CNOT2 [cytosol]

Stable Identifier

R-HSA-429902

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CCR4-NOT transcription complex subunit 2, CNOT2_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)
        
        BTG2 binds CCR4-NOT complex (Homo sapiens)
        
        BTG2:CCR4-NOT [cytosol] (Homo sapiens)
        
        CCR4-NOT Complex [cytosol] (Homo sapiens)
        
        CNOT2 [cytosol] (Homo sapiens)
        
        CCR4-NOT Complex [cytosol] (Homo sapiens)
        
        CNOT2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NZN8 CNOT2

Gene Names

CNOT2, CDC36, NOT2, HSPC131, MSTP046

Chain

chain:1-540

Reference Genes

BioGPS Gene:4848 CNOT2

COSMIC (genes):CNOT2 CNOT2

CTD Gene:4848 CNOT2

dbSNP Gene:4848 CNOT2

ENSEMBL:ENSG00000111596 CNOT2

HGNC:7878 CNOT2

KEGG Gene (Homo sapiens):4848 CNOT2

Monarch:4848 CNOT2

NCBI Gene:4848 CNOT2

OMIM:604909 CNOT2

UCSC:Q9NZN8 CNOT2

Reference Transcript

Other Identifiers

0006380253

0106020167

11734936_a_at

11734937_a_at

11757803_x_at

217798_at

222182_s_at

33861_at

3421902

3421903

3421904

3421905

3421906

3421907

3421908

3421909

3421910

3421911

3421912

3421913

3421921

3421922

3421934

3421936

3421937

3421943

3421944

3421945

3421946

3421947

3421948

3421949

3421950

3421951

3421952

3421953

3421954

3421955

3421956

3421957

3421958

3421959

3421960

3421962

3421965

3421968

3421972

3421973

3421974

3421975

3421976

3421977

3421978

4848

72303_at

7957106

90977_at

A_19_P00328397

A_23_P162336

A_23_P421147

A_24_P8049

A_33_P3287690

GE81936

GO:0000122

GO:0000278

GO:0000289

GO:0000932

GO:0001226

GO:0001829

GO:0003674

GO:0003712

GO:0004518

GO:0004535

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006355

GO:0006357

GO:0006412

GO:0006417

GO:0006950

GO:0006977

GO:0007049

GO:0007165

GO:0007275

GO:0008134

GO:0008150

GO:0009056

GO:0009058

GO:0009790

GO:0010606

GO:0016020

GO:0022607

GO:0030014

GO:0030015

GO:0030154

GO:0031047

GO:0032991

GO:0033147

GO:0034641

GO:0034655

GO:0043226

GO:0048646

GO:0048856

GO:0090503

GO:2000036

HMNXSV003024520

HMNXSV003025484

Hs.239720.0.S2_3p_at

ILMN_1772651

PH_hs_0031951

TC12000620.hg

TC12002443.hg

Participates

as a component of

CCR4-NOT Complex [cytosol] (Homo sapiens)

Inferred To

Ghost homologue of CNOT2 [cytosol] (Canis familiaris)

Cnot2 [cytosol] (Mus musculus)

Cnot2 [cytosol] (Rattus norvegicus)

cnot2 [cytosol] (Danio rerio)

cnot2 [cytosol] (Xenopus tropicalis)

CNOT2 [cytosol] (Bos taurus)

CNOT2 [cytosol] (Dictyostelium discoideum)

CNOT2 [cytosol] (Gallus gallus)

CNOT2 [cytosol] (Sus scrofa)

Cross References

RefSeq

XP_011536701.1, NP_001186231.1, NP_055330.1, NP_001186232.1

OpenTargets

ENSG00000111596

GeneCards

Q9NZN8

HPA

ENSG00000111596-CNOT2

Ensembl

ENSP00000448883, ENSP00000449260, ENSG00000111596, ENST00000229195, ENST00000418359, ENST00000551483, ENST00000551043, ENSP00000229195, ENSP00000412091

PRO

Q9NZN8

Pharos - Targets

Q9NZN8

GlyGen

Q9NZN8

Orphanet

28625

PDB

4C0F, 4C0D, 5FU6, 5FU7

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P41182 BCL6	1	BCL6 [nucleoplasm] (R-HSA-5223066)	0.556	3
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.556	3
UniProt:Q92600 CNOT9	2	RQCD1 [cytosol] (R-HSA-430029) RQCD1 [nucleoplasm] (R-HSA-6810130)	0.508	2