Reactome | DOK4 [cytosol]

DOK4 [cytosol]

Stable Identifier

R-HSA-8847701

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Docking protein 4, Downstream of tyrosine kinase 4, Insulin receptor substrate 5, IRS5

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8TEW6 DOK4

Gene Names

DOK4

Chain

chain:1-326

Reference Genes

BioGPS Gene:55715 DOK4

COSMIC (genes):DOK4 DOK4

CTD Gene:55715 DOK4

dbSNP Gene:55715 DOK4

ENSEMBL:ENSG00000125170 DOK4

HGNC:19868 DOK4

Monarch:55715 DOK4

NCBI Gene:55715 DOK4

OMIM:608333 DOK4

UCSC:Q8TEW6 DOK4

Reference Transcript

Other Identifiers

11718822_a_at

11756377_s_at

16826779

207747_PM_s_at

207747_s_at

209690_PM_s_at

209690_s_at

209691_PM_s_at

209691_s_at

32600_at

3693215

3693216

3693217

3693218

3693219

3693220

3693221

3693222

3693223

3693224

3693225

3693226

3693227

3693228

3693229

3693230

3693232

3693233

3693234

3693235

3693237

3693238

3693239

55715

74954_at

8001564

80686_at

A_23_P77381

A_24_P48069

GE62296

GO:0005515

GO:0005737

GO:0005829

GO:0007169

GO:0007265

GO:0007399

GO:0043410

GO:0048856

HMNXSV003021685

Hs.279832.1.A1_3p_a_at

ILMN_1774261

PH_hs_0014407

TC16001140.hg

g13097653_3p_s_at

g8922455_3p_s_at

Participates

as a member of

DOK1,DOK2,DOK4,DOK5,DOK6 [cytosol] (Homo sapiens)

Inferred To

rog-1 [cytosol] (Caenorhabditis elegans)

Dok4 [cytosol] (Mus musculus)

Dok4 [cytosol] (Rattus norvegicus)

DOK4 [cytosol] (Bos taurus)

DOK4 [cytosol] (Canis familiaris)

DOK4 [cytosol] (Gallus gallus)

DOK4 [cytosol] (Sus scrofa)

Dok [cytosol] (Drosophila melanogaster)

Cross References

ENSEMBL

ENSP00000344277, ENST00000340099, ENSP00000455128, ENST00000569548

OpenTargets

ENSG00000125170

HPA

ENSG00000125170-DOK4

PRO

Q8TEW6

Pharos - Targets

Q8TEW6

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35372 OPRM1	1	OPRM1 [plasma membrane] (R-HSA-60951)	0.581	4
UniProt:Q06710 PAX8	1	PAX8 [nucleoplasm] (R-HSA-3968418)	0.556	3
UniProt:Q9HCG8 CWC22	1	CWC22 [nucleoplasm] (R-HSA-8865956)	0.527	2
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.527	2
UniProt:P52630 STAT2	4	p-Y690-STAT2 [cytosol] (R-HSA-909683) STAT2 [cytosol] (R-HSA-882029) p-Y690-STAT2 [nucleoplasm] (R-HSA-909673) p-Y-STAT2 [cytosol] (R-HSA-8987235)	0.488	2
UniProt:Q05397 PTK2	11	p-6Y-PTK2 [cytosol] (R-HSA-354128) p-Y397-PTK2 [cytosol] (R-HSA-354068) PTK2 [cytosol] (R-HSA-201621) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2(773-1052) [cytosol] (R-HSA-202829) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) pY-PTK2 [cytosol] (R-HSA-9632393) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613)	0.488	2