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REV1 [nucleoplasm]
Stable Identifier
R-HSA-3006726
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
DNA repair protein REV1 ecNumber2.7.7.-/ecNumber, REV1_HUMAN
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Damage Bypass (Homo sapiens)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Homo sapiens)
Termination of translesion DNA synthesis (Homo sapiens)
TRIM25 binds monoUb:164-PCNA (Homo sapiens)
DNA polymerase Y:MonoUb:K164-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
DNA polymerase Y [nucleoplasm] (Homo sapiens)
REV1 [nucleoplasm] (Homo sapiens)
UBE2L6:TRIM25:DNA polymerase Y:MonoUb:K164-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
DNA polymerase Y:MonoUb:K164-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
DNA polymerase Y [nucleoplasm] (Homo sapiens)
REV1 [nucleoplasm] (Homo sapiens)
UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Homo sapiens)
DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
DNA polymerase Y [nucleoplasm] (Homo sapiens)
REV1 [nucleoplasm] (Homo sapiens)
UBE2L6:TRIM25:DNA polymerase Y:MonoUb:K164-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
DNA polymerase Y:MonoUb:K164-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
DNA polymerase Y [nucleoplasm] (Homo sapiens)
REV1 [nucleoplasm] (Homo sapiens)
USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Homo sapiens)
DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
DNA polymerase Y [nucleoplasm] (Homo sapiens)
REV1 [nucleoplasm] (Homo sapiens)
USP10:DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
DNA polymerase Y [nucleoplasm] (Homo sapiens)
REV1 [nucleoplasm] (Homo sapiens)
USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Homo sapiens)
DNA polymerase Y [nucleoplasm] (Homo sapiens)
REV1 [nucleoplasm] (Homo sapiens)
USP10:DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
DNA polymerase Y [nucleoplasm] (Homo sapiens)
REV1 [nucleoplasm] (Homo sapiens)
Translesion synthesis by POLI (Homo sapiens)
POLI incorporates dNMP opposite to damaged DNA base (Homo sapiens)
POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(EtAD:T)-DNA Template,(Gamma-HOPdG:C)-DNA Template [nucleoplasm] (Homo sapiens)
REV1 [nucleoplasm] (Homo sapiens)
POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template [nucleoplasm] (Homo sapiens)
REV1 [nucleoplasm] (Homo sapiens)
POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Homo sapiens)
POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template [nucleoplasm] (Homo sapiens)
REV1 [nucleoplasm] (Homo sapiens)
REV1 [nucleoplasm] (Homo sapiens)
POLZ elongates POLI-incorporated dNMP (Homo sapiens)
POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(EtAD:T)-DNA Template,(Gamma-HOPdG:C)-DNA Template [nucleoplasm] (Homo sapiens)
REV1 [nucleoplasm] (Homo sapiens)
REV1 [nucleoplasm] (Homo sapiens)
Translesion synthesis by POLK (Homo sapiens)
POLK and POLZ cooperate in elongation of mispaired primer termini (Homo sapiens)
POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm] (Homo sapiens)
REV1 [nucleoplasm] (Homo sapiens)
REV1 [nucleoplasm] (Homo sapiens)
POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Homo sapiens)
POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm] (Homo sapiens)
REV1 [nucleoplasm] (Homo sapiens)
REV1 [nucleoplasm] (Homo sapiens)
POLK incorporates dNMP opposite to damaged DNA base (Homo sapiens)
POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm] (Homo sapiens)
REV1 [nucleoplasm] (Homo sapiens)
POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm] (Homo sapiens)
REV1 [nucleoplasm] (Homo sapiens)
Translesion synthesis by REV1 (Homo sapiens)
POLZ extends translesion synthesis (Homo sapiens)
POLZ:REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Homo sapiens)
REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Homo sapiens)
REV1 [nucleoplasm] (Homo sapiens)
REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt-mispairedPolydNMP)-DNA Template [nucleoplasm] (Homo sapiens)
REV1 [nucleoplasm] (Homo sapiens)
REV1 binds AP-dsDNA (Homo sapiens)
REV1 [nucleoplasm] (Homo sapiens)
REV1:MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm] (Homo sapiens)
REV1 [nucleoplasm] (Homo sapiens)
REV1 inserts dCMP opposite to AP sites in DNA (Homo sapiens)
REV1 [nucleoplasm] (Homo sapiens)
REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Homo sapiens)
REV1 [nucleoplasm] (Homo sapiens)
REV1:MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm] (Homo sapiens)
REV1 [nucleoplasm] (Homo sapiens)
REV1 recruits POLZ to (AP:Cyt)-DNA Template (Homo sapiens)
POLZ:REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Homo sapiens)
REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Homo sapiens)
REV1 [nucleoplasm] (Homo sapiens)
REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Homo sapiens)
REV1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UBZ9 REV1
Gene Names
REV1, REV1L
Chain
chain:1-1251
Reference Genes
BioGPS Gene:51455 REV1
COSMIC (genes):REV1 REV1
CTD Gene:51455 REV1
dbSNP Gene:51455 REV1
ENSEMBL:ENSG00000135945 REV1
ENSEMBL:ENSG00000135945.10 REV1
HGNC:14060 REV1
KEGG Gene (Homo sapiens):51455 REV1
Monarch:51455 REV1
NCBI Gene:51455 REV1
OMIM:606134 REV1
UCSC:Q9UBZ9 REV1
Reference Transcript
RefSeq:NM_001321455.1 REV1
RefSeq:NM_001321454.1 REV1
RefSeq:NM_001321459.1 REV1
RefSeq:NM_001321458.1 REV1
RefSeq:NM_016316.3 REV1
RefSeq:NM_001321460.1 REV1
RefSeq:NM_001037872.2 REV1
Other Identifiers
11722897_a_at
11722898_s_at
11722899_a_at
16901027
218428_PM_s_at
218428_s_at
222628_PM_s_at
222628_s_at
222629_PM_at
222629_at
2566765
2566766
2566767
2566769
2566771
2566772
2566773
2566774
2566775
2566777
2566779
2566781
2566782
2566784
2566785
2566788
2566789
2566791
2566794
2566795
2566797
2566802
2566808
2566809
2566812
2566813
2566815
2566817
2566818
2566819
2566823
2566825
2566831
43956_at
51455
51821_at
63358_at
8054227
A_23_P32970
A_24_P256325
A_24_P291426
GE54959
GO:0003677
GO:0003684
GO:0003824
GO:0003887
GO:0005515
GO:0005634
GO:0005654
GO:0006259
GO:0006260
GO:0006281
GO:0006974
GO:0009411
GO:0016740
GO:0016779
GO:0017125
GO:0042276
GO:0043226
GO:0046872
GO:0050896
GO:0070987
GO:0071897
GO:0140097
HMNXSV003003818
HMNXSV003025857
HMNXSV003045803
Hs.110347.0.S1_3p_a_at
Hs.110347.0.S3_3p_at
ILMN_1707062
ILMN_2395474
PH_hs_0025877
TC02002135.hg
g7706680_3p_a_at
Participates
as a member of
DNA polymerase Y [nucleoplasm] (Homo sapiens)
as an output of
POLZ elongates POLI-incorporated dNMP (Homo sapiens)
POLK and POLZ cooperate in elongation of mispaired primer termini (Homo sapiens)
as an input of
POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Homo sapiens)
REV1 binds AP-dsDNA (Homo sapiens)
POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Homo sapiens)
as a component of
POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(EtAD:T)-DNA Template,(Gamma-HOPdG:C)-DNA Template [nucleoplasm] (Homo sapiens)
POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template [nucleoplasm] (Homo sapiens)
REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt-mispairedPolydNMP)-DNA Template [nucleoplasm] (Homo sapiens)
REV1:MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm] (Homo sapiens)
REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Homo sapiens)
POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm] (Homo sapiens)
POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm] (Homo sapiens)
Inferred To
Rev1 [nucleoplasm]
(Rattus norvegicus)
si:dkey-57a22.7 [nucleoplasm]
(Danio rerio)
REV1 [nucleoplasm]
(Bos taurus)
REV1 [nucleoplasm]
(Canis familiaris)
REV1 [nucleoplasm]
(Drosophila melanogaster)
REV1 [nucleoplasm]
(Gallus gallus)
REV1 [nucleoplasm]
(Mus musculus)
REV1 [nucleoplasm]
(Plasmodium falciparum)
REV1 [nucleoplasm]
(Saccharomyces cerevisiae)
REV1 [nucleoplasm]
(Schizosaccharomyces pombe)
REV1 [nucleoplasm]
(Sus scrofa)
rev-1 [nucleoplasm]
(Caenorhabditis elegans)
rev1 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001308383.1
,
NP_001308387.1
,
NP_001032961.1
,
NP_001308389.1
,
NP_001308388.1
,
NP_001308384.1
,
NP_057400.1
OpenTargets
ENSG00000135945
GeneCards
Q9UBZ9
HPA
ENSG00000135945-REV1
Ensembl
ENST00000258428
,
ENST00000393445
,
ENSP00000258428
,
ENSP00000377091
,
ENSG00000135945
PRO
Q9UBZ9
Pharos - Targets
Q9UBZ9
PDB
4BA9
,
3GQC
,
6AXD
,
2LSK
,
3VU7
,
5VZM
,
2LSI
,
4GK0
,
2LSY
,
6WS0
,
2EBW
,
4EXT
,
6ASR
,
6WS5
,
2N1G
,
4GK5
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UI95 MAD2L2
1
MAD2L2 [nucleoplasm]
(R-HSA-59092)
0.591
4
UniProt:Q6NZ36 FAAP20
2
FAAP20 [nucleoplasm]
(R-HSA-6783321)
FAAP20 [cytosol]
(R-HSA-9835400)
0.544
2
UniProt:Q14192 FHL2
1
FHL2 [nucleoplasm]
(R-HSA-561161)
0.508
2
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