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DSN1 [cytosol]
Stable Identifier
R-HSA-375308
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
Mitotic Spindle Checkpoint (Homo sapiens)
Amplification of signal from the kinetochores (Homo sapiens)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
Mad1 binds kinetochore (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
Release of activated MAD2 from kinetochores (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
Separation of sister chromatids (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
EML4 and NUDC in mitotic spindle formation (Homo sapiens)
EML4 recruits NUDC to mitotic spindle (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
Resolution of Sister Chromatid Cohesion (Homo sapiens)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
Kinetochore assembly (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
AURKB phosphorylates DIAPH2-2 at kinetochores (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
DSN1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H410 DSN1
Gene Names
DSN1, C20orf172, MIS13
Chain
chain:1-356
Reference Genes
BioGPS Gene:79980 DSN1
COSMIC (genes):DSN1 DSN1
CTD Gene:79980 DSN1
dbSNP Gene:79980 DSN1
ENSEMBL:ENSG00000149636.16 DSN1
HGNC:16165 DSN1
KEGG Gene (Homo sapiens):79980 DSN1
Monarch:79980 DSN1
NCBI Gene:79980 DSN1
OMIM:609175 DSN1
UCSC:Q9H410 DSN1
Reference Transcript
RefSeq:NM_001145318.1 DSN1
RefSeq:NM_024918.3 DSN1
RefSeq:NM_001145315.1 DSN1
RefSeq:XM_006723876.2 DSN1
RefSeq:NM_001145316.1 DSN1
RefSeq:NM_001145317.1 DSN1
Other Identifiers
11715331_x_at
16918976
219512_3p_at
219512_PM_at
219512_at
3904567
3904568
3904569
3904570
3904571
3904572
3904573
3904575
3904577
3904578
3904580
3904581
3904582
3904583
3904584
3904586
3904589
3904590
3904591
3904592
46983_at
67147_at
79980
8066074
A_23_P165937
GE83002
GO:0000070
GO:0000278
GO:0000444
GO:0000775
GO:0000776
GO:0001650
GO:0005515
GO:0005576
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005764
GO:0005773
GO:0005829
GO:0007049
GO:0007059
GO:0016604
GO:0031410
GO:0035578
GO:0043226
GO:0051301
GO:0140014
HMNXSV003018422
ILMN_1715905
PH_hs_0013673
TC20000818.hg
g13376387_3p_at
g13376387_3p_x_at
Participates
as a component of
Mis12 complex [cytosol] (Homo sapiens)
Other forms of this molecule
DSN1 [extracellular region]
DSN1 [azurophil granule lumen]
Inferred To
Dsn1 [cytosol]
(Mus musculus)
Dsn1 [cytosol]
(Rattus norvegicus)
DSN1 [cytosol]
(Bos taurus)
DSN1 [cytosol]
(Canis familiaris)
DSN1 [cytosol]
(Sus scrofa)
Dsn1/Q9H410 [cytosol]
(Gallus gallus)
dsn1 [cytosol]
(Danio rerio)
dsn1 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001138789.1
,
NP_001138787.1
,
NP_079194.3
,
NP_001138790.1
,
XP_006723939.1
,
NP_001138788.1
OpenTargets
ENSG00000149636
GeneCards
Q9H410
HPA
ENSG00000149636-DSN1
Ensembl
ENST00000373734
,
ENSG00000149636
,
ENSP00000362855
,
ENSP00000362839
,
ENSP00000404463
,
ENST00000373750
,
ENSP00000389810
,
ENST00000426836
,
ENST00000448110
PRO
Q9H410
Pharos - Targets
Q9H410
PDB
5LSJ
,
5LSK
,
5LSI
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P45973 CBX5
2
CBX5 [nucleoplasm]
(R-HSA-994093)
monoSUMO1-K84,K-CBX5 [nucleoplasm]
(R-HSA-4615849)
0.788
7
UniProt:O14964 HGS
2
HGS [cytosol]
(R-HSA-182954)
HGS [phagocytic vesicle lumen]
(R-HSA-9635660)
0.556
3
UniProt:Q13185 CBX3
1
CBX3 [nucleoplasm]
(R-HSA-427386)
0.527
3
UniProt:P83916 CBX1
1
CBX1 [nucleoplasm]
(R-HSA-9653629)
0.527
2
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