Reactome | ATF3 [nucleoplasm]

ATF3 [nucleoplasm]

Stable Identifier

R-HSA-535543

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Cyclic AMP-dependent transcription factor ATF-3, ATF3_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P18847 ATF3

Gene Names

ATF3

Chain

chain:1-181

Reference Genes

BioGPS Gene:467 ATF3

COSMIC (genes):ATF3 ATF3

CTD Gene:467 ATF3

dbSNP Gene:467 ATF3

ENSEMBL:ENSG00000162772 ATF3

ENSEMBL:ENSG00000162772.17 ATF3

HGNC:785 ATF3

KEGG Gene (Homo sapiens):467 ATF3

Monarch:467 ATF3

NCBI Gene:467 ATF3

OMIM:603148 ATF3

UCSC:P18847 ATF3

Reference Transcript

Other Identifiers

11719342_a_at

11719343_x_at

11719344_a_at

11742243_a_at

11753631_a_at

11753632_x_at

1554420_PM_at

1554420_at

1554980_PM_a_at

1554980_a_at

16677278

202672_PM_s_at

202672_s_at

2379133

2379135

2379136

2379140

2379141

2379142

2379147

2379149

2379150

2379151

2379152

2379153

2379154

2379167

287_at

467

7909610

A_14_P108482

A_23_P34915

A_24_P33895

A_33_P3214096

A_33_P3214105

GE58321

GE81053

GO:0000122

GO:0000785

GO:0000976

GO:0000977

GO:0000978

GO:0000981

GO:0001227

GO:0001228

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005975

GO:0006094

GO:0006351

GO:0006355

GO:0006357

GO:0008284

GO:0010033

GO:0010628

GO:0012501

GO:0023052

GO:0030154

GO:0030968

GO:0034198

GO:0035914

GO:0042802

GO:0042803

GO:0043226

GO:0045892

GO:0045944

GO:0046982

GO:0048856

GO:0070373

GO:0090575

GO:0140110

GO:1903984

GO:1990440

GO:1990622

GO:1990837

HMNXSV003011482

Hs2.460.3.A1_3p_at

Hs2.460.3.A1_3p_x_at

ILMN_1661109

ILMN_1791346

ILMN_2374865

L19871_at

PH_hs_0000057

TC01001777.hg

g4502262_3p_s_at

Participates

as an input of

ATF4, CEBPB, and ATF3 bind the CHAC1 promoter (Homo sapiens)

as a component of

ATF3:ATF4:CEBPB:CHAC1 gene [nucleoplasm] (Homo sapiens)

as an output of

Expression of ATF3 (Homo sapiens)

Cross References

RefSeq

NP_001025458.1, NP_001035709.1, XP_005273203.1, NP_001193413.2, XP_011507881.1, NP_001665.1, NP_001193417.2, NP_001193415.1

OpenTargets

ENSG00000162772

GeneCards

P18847

HPA

ENSG00000162772-ATF3

Ensembl

ENST00000464547, ENSG00000162772, ENSP00000344352, ENST00000613104, ENSP00000432208, ENST00000366987, ENST00000341491, ENST00000366983, ENSP00000355950, ENSP00000355954, ENSP00000480606, ENSP00000336908, ENST00000336937

PRO

P18847

Pharos - Targets

P18847

HMDB Protein

HMDBP08113

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35638 DDIT3	1	DDIT3 [nucleoplasm] (R-HSA-381110)	0.946	23
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.806	9
UniProt:P18848 ATF4	2	ATF4 [cytosol] (R-HSA-381084) ATF4 [nucleoplasm] (R-HSA-381016)	0.799	9
UniProt:P17275 JUNB	1	JUNB [nucleoplasm] (R-HSA-2186795)	0.779	6
UniProt:P53567 CEBPG	1	CEBPG [nucleoplasm] (R-HSA-9644320)	0.713	5
UniProt:Q9NR55 BATF3			0.713	5
UniProt:P15336 ATF2	2	ATF2 [nucleoplasm] (R-HSA-450336) p-T69,T71-ATF2 [nucleoplasm] (R-HSA-450243)	0.713	5
UniProt:P18847 ATF3	1	ATF3 [nucleoplasm] (R-HSA-535543)	0.667	3
UniProt:Q16236 NFE2L2	13	p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-NFE2L2 [cytosol] (R-HSA-9758077) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109)	0.625	5
UniProt:P17535 JUND	1	JUND [nucleoplasm] (R-HSA-9009924)	0.59	3
UniProt:P17544 ATF7			0.59	3
UniProt:D3DTS7 D3DTS7			0.556	3
UniProt:P54253 ATX1			0.556	6
UniProt:P09936 UCHL1	1	UCHL1 [cytosol] (R-HSA-5660679)	0.556	3
UniProt:Q14203-5 DCTN1			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q92870-2 Q928702			0.556	3
UniProt:Q13148 TADBP			0.556	6
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.556	3
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.508	3
UniProt:O95644 NFATC1	3	p-S257-NFATC1 [nucleoplasm] (R-HSA-2025935) p-S257-NFATC1 [cytosol] (R-HSA-2685618) p-12S-NFATC1 [cytosol] (R-HSA-2025953)	0.499	2
UniProt:O60880 SH2D1A	1	SH2D1A [cytosol] (R-HSA-5685108)	0.488	2

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