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YY1 [nucleoplasm]
Stable Identifier
R-HSA-4086091
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Transcriptional repressor protein YY1, TYY1_HUMAN
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
DNA Damage Recognition in GG-NER (Homo sapiens)
XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Homo sapiens)
INO80 complex [nucleoplasm] (Homo sapiens)
YY1 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Activation of HOX genes during differentiation (Homo sapiens)
Activation of anterior HOX genes in hindbrain development during early embryogenesis (Homo sapiens)
HOXD4 gene is transcribed (Homo sapiens)
YY1 [nucleoplasm] (Homo sapiens)
atRA:RARA,B:RXRA at active HOXD4 chromatin [nucleoplasm] (Homo sapiens)
YY1 [nucleoplasm] (Homo sapiens)
Retinoic acid activates HOXD4 chromatin (Homo sapiens)
RARA,B:RXRA at HOXD4 bivalent chromatin [nucleoplasm] (Homo sapiens)
YY1 [nucleoplasm] (Homo sapiens)
atRA:RARA,B:RXRA at active HOXD4 chromatin [nucleoplasm] (Homo sapiens)
YY1 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (Homo sapiens)
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors (Homo sapiens)
TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers and YY1 stimulate ERBB2 gene expression (Homo sapiens)
TFAP2A,(TFAP2B,TFAP2C) dimers:YY1 [nucleoplasm] (Homo sapiens)
YY1 [nucleoplasm] (Homo sapiens)
TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers:YY1:ERBB2 gene [nucleoplasm] (Homo sapiens)
TFAP2A,(TFAP2B,TFAP2C) dimers:YY1 [nucleoplasm] (Homo sapiens)
YY1 [nucleoplasm] (Homo sapiens)
TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers bind the ERBB2 gene promoter and recruit YY1 (Homo sapiens)
TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers:YY1:ERBB2 gene [nucleoplasm] (Homo sapiens)
TFAP2A,(TFAP2B,TFAP2C) dimers:YY1 [nucleoplasm] (Homo sapiens)
YY1 [nucleoplasm] (Homo sapiens)
YY1 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
UCH proteinases (Homo sapiens)
BAP1 binds BAP1-interacting complex (Homo sapiens)
BAP1-interacting complex [nucleoplasm] (Homo sapiens)
YY1 [nucleoplasm] (Homo sapiens)
BAP1:BAP1-interacting complex [nucleoplasm] (Homo sapiens)
BAP1-interacting complex [nucleoplasm] (Homo sapiens)
YY1 [nucleoplasm] (Homo sapiens)
UCHL5 binds INO80 complex (Homo sapiens)
INO80 complex [nucleoplasm] (Homo sapiens)
YY1 [nucleoplasm] (Homo sapiens)
UCHL5:INO80 complex [nucleoplasm] (Homo sapiens)
INO80 complex [nucleoplasm] (Homo sapiens)
YY1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Estrogen-dependent gene expression (Homo sapiens)
FOXA1 and GATA3 bind to CCND1 promoter (Homo sapiens)
CCND1 gene:H3K4me2 nucleosome:YY1:HDAC1 [nucleoplasm] (Homo sapiens)
YY1 [nucleoplasm] (Homo sapiens)
YY1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P25490 YY1
Gene Names
YY1, INO80S
Chain
chain:1-414
Reference Genes
BioGPS Gene:7528 YY1
COSMIC (genes):YY1 YY1
CTD Gene:7528 YY1
dbSNP Gene:7528 YY1
ENSEMBL:ENSG00000100811.14 YY1
ENSEMBL:ENSG00000100811.15 YY1
HGNC:12856 YY1
KEGG Gene (Homo sapiens):7528 YY1
Monarch:7528 YY1
NCBI Gene:7528 YY1
OMIM:600013 YY1
UCSC:P25490 YY1
Reference Transcript
RefSeq:NM_003403.4 YY1
Other Identifiers
11724730_at
11724731_a_at
11758914_at
11758915_a_at
11758916_at
11764091_x_at
16788384
18671130
18671132
18671134
18671136
18671137
200047_PM_s_at
200047_s_at
201901_PM_s_at
201901_s_at
201902_3p_s_at
201902_PM_s_at
201902_s_at
224711_PM_at
224711_at
224718_PM_at
224718_at
33209_at
3551689
3551690
3551691
3551692
3551693
3551694
3551695
3551706
3551718
3551721
3551723
3551724
3551725
3551726
3551727
3551728
44692_at
48339_at
7528
7893039
7893500
7893926
7893941
7893981
7894375
7894581
7894683
7894791
7894846
7895879
7896352
7896490
7896493
7976744
891_at
A_14_P133736
A_24_P219140
A_24_P916288
A_33_P3315600
GE58300
GE85965
GO:0000122
GO:0000228
GO:0000400
GO:0000723
GO:0000724
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0000987
GO:0001217
GO:0001227
GO:0001228
GO:0002376
GO:0003012
GO:0003677
GO:0003682
GO:0003700
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005677
GO:0005694
GO:0005737
GO:0006260
GO:0006275
GO:0006281
GO:0006282
GO:0006310
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006357
GO:0006403
GO:0006974
GO:0007283
GO:0009952
GO:0010225
GO:0010467
GO:0010628
GO:0010629
GO:0016363
GO:0022414
GO:0030097
GO:0030154
GO:0030183
GO:0031011
GO:0031519
GO:0032200
GO:0032688
GO:0033044
GO:0034644
GO:0034696
GO:0043226
GO:0043565
GO:0045739
GO:0045893
GO:0045944
GO:0045995
GO:0046332
GO:0046872
GO:0048593
GO:0048856
GO:0051276
GO:0051726
GO:0060382
GO:0061052
GO:0071347
GO:0071707
GO:0140110
GO:0140297
GO:1902894
GO:1904507
GO:1990837
HMNXSV003002787
Hs.296322.0.S2_3p_at
Hs.296322.0.S3_3p_at
Hs.97496.0.S1_3p_a_at
Hs.97496.0.S3_3p_s_at
ILMN_1770892
ILMN_2181540
M77698_at
PH_hs_0024486
TC14000632.hg
TC14001851.hg
TC14001852.hg
TC14001853.hg
g6042207_3p_a_at
p25918
Participates
as a component of
BAP1-interacting complex [nucleoplasm] (Homo sapiens)
TFAP2A,(TFAP2B,TFAP2C) dimers:YY1 [nucleoplasm] (Homo sapiens)
RARA,B:RXRA at HOXD4 bivalent chromatin [nucleoplasm] (Homo sapiens)
atRA:RARA,B:RXRA at active HOXD4 chromatin [nucleoplasm] (Homo sapiens)
INO80 complex [nucleoplasm] (Homo sapiens)
CCND1 gene:H3K4me2 nucleosome:YY1:HDAC1 [nucleoplasm] (Homo sapiens)
as an input of
TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers bind the ERBB2 gene promoter and recruit YY1 (Homo sapiens)
as an output of
FOXA1 and GATA3 bind to CCND1 promoter (Homo sapiens)
Inferred To
YY2 [nucleoplasm]
(Gallus gallus)
Yy1 [nucleoplasm]
(Mus musculus)
Yy1 [nucleoplasm]
(Rattus norvegicus)
yy1 [nucleoplasm]
(Xenopus tropicalis)
pho [nucleoplasm]
(Drosophila melanogaster)
YY1 [nucleoplasm]
(Bos taurus)
YY1 [nucleoplasm]
(Canis familiaris)
YY1 [nucleoplasm]
(Sus scrofa)
fb59g10 [nucleoplasm]
(Danio rerio)
Cross References
RefSeq
NP_003394.1
OpenTargets
ENSG00000100811
GeneCards
P25490
HPA
ENSG00000100811-YY1
Ensembl
ENSP00000262238
,
ENSG00000100811
,
ENST00000262238
PRO
P25490
Pharos - Targets
P25490
Orphanet
25043
PDB
1UBD
,
4C5I
,
1ZNM
Interactors (64)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8NBZ0 INO80E
1
INO80E [nucleoplasm]
(R-HSA-5689552)
0.848
8
UniProt:Q9ULG1 INO80
1
INO80 [nucleoplasm]
(R-HSA-5688910)
0.82
9
UniProt:Q9Y230 RUVBL2
1
RUVBL2 [nucleoplasm]
(R-HSA-418321)
0.81
8
UniProt:O96019 ACTL6A
1
ACTL6A [nucleoplasm]
(R-HSA-2980912)
0.78
7
UniProt:Q9Y265 RUVBL1
1
RUVBL1 [nucleoplasm]
(R-HSA-418323)
0.757
6
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [cytosol]
(R-HSA-1629778)
UCHL5 [nucleoplasm]
(R-HSA-5689584)
0.745
5
UniProt:Q9H981 ACTR8
1
ACTR8 [nucleoplasm]
(R-HSA-5689565)
0.745
5
UniProt:Q9H9F9 ACTR5
1
ACTR5 [nucleoplasm]
(R-HSA-5688913)
0.745
5
UniProt:Q96EZ8 MCRS1
1
MCRS1 [nucleoplasm]
(R-HSA-3321849)
0.671
4
UniProt:P0C1Z6 TFPT
1
TFPT [nucleoplasm]
(R-HSA-5689542)
0.671
4
UniProt:Q6P4R8 NFRKB
1
NFRKB [nucleoplasm]
(R-HSA-5689578)
0.671
4
UniProt:P28799 GRN
2
GRN [azurophil granule lumen]
(R-HSA-6799168)
GRN [extracellular region]
(R-HSA-6806217)
0.666
4
UniProt:Q969G2 LHX4
1
LHX4 [nucleoplasm]
(R-HSA-9010585)
0.659
4
UniProt:Q53TQ3 INO80D
1
INO80D [nucleoplasm]
(R-HSA-5689559)
0.643
3
UniProt:Q9H869 YYAP1
0.632
5
UniProt:Q8JSK4 Q8JSK4
0.616
4
UniProt:P49407 ARRB1
5
ARRB1 [cytosol]
(R-HSA-264470)
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.602
4
UniProt:Q8IY57 YAF2
1
YAF2 [nucleoplasm]
(R-HSA-8937973)
0.593
4
UniProt:P03259 E1A
0.581
3
UniProt:Q9H869-2 YY1AP1
0.581
4
UniProt:Q9C086 INO80B
1
INO80B [nucleoplasm]
(R-HSA-5689599)
0.569
3
UniProt:Q6PI98 INO80C
1
INO80C [nucleoplasm]
(R-HSA-5689605)
0.569
3
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:Q7Z699 SPRED1
2
SPRED1 [plasma membrane]
(R-HSA-5658225)
SPRED1 [cytosol]
(R-HSA-5654207)
0.556
3
UniProt:Q99750 MDFI
0.556
3
UniProt:Q9BYR2 KRTAP4-5
1
KRTAP4-5 [cytosol]
(R-HSA-6809950)
0.556
3
UniProt:Q9HD64 XAGE1
0.556
3
UniProt:Q8IWZ5 TRI42
0.556
3
UniProt:Q9BYR5 KRTAP4-2
1
KRTAP4-2 [cytosol]
(R-HSA-6809948)
0.556
3
UniProt:P60328 KRTAP12-3
1
KRTAP12-3 [cytosol]
(R-HSA-6810284)
0.556
3
UniProt:Q9BYR9 KRTAP2-4
1
KRTAP2-4 [cytosol]
(R-HSA-6809951)
0.556
3
UniProt:Q9UBR4-2 LHX3
0.556
3
UniProt:Q96IK5 GMCL1
0.556
5
UniProt:P54725 RAD23A
1
RAD23A [nucleoplasm]
(R-HSA-5688076)
0.556
3
UniProt:Q9BYS1 KRTAP1-5
1
KRTAP1-5 [cytosol]
(R-HSA-6809867)
0.556
3
UniProt:Q9NQ30 ESM1
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
UniProt:P59991 KRTAP12-2
1
KRTAP12-2 [cytosol]
(R-HSA-6810271)
0.556
3
UniProt:Q8IUG1 KRTAP1-3
1
KRTAP1-3 [cytosol]
(R-HSA-6809866)
0.556
3
UniProt:Q49A12 Q49A12
0.556
3
UniProt:Q8TAP6 CEP76
1
CEP76 [cytosol]
(R-HSA-380281)
0.556
3
UniProt:Q9BYP8 KRTAP17-1
1
KRTAP17-1 [cytosol]
(R-HSA-6809980)
0.556
3
UniProt:P28799-2 GRN
0.556
3
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
UniProt:P60411 KRTAP10-9
1
KRTAP10-9 [cytosol]
(R-HSA-6810277)
0.556
3
UniProt:Q6L8G9 KRTAP5-6
1
KRTAP5-6 [cytosol]
(R-HSA-6810276)
0.556
3
UniProt:Q2TAL6 VWC2
0.556
3
UniProt:Q9H8W4 PKHF2
0.556
3
UniProt:P60370 KRTAP10-5
1
KRTAP10-5 [cytosol]
(R-HSA-6810260)
0.556
3
UniProt:G5E9A7 G5E9A7
0.556
3
UniProt:O15354 GPR37
1
GPR37 [plasma membrane]
(R-HSA-5333623)
0.556
3
UniProt:Q9BYQ0 KRTAP9-8
1
KRTAP9-8 [cytosol]
(R-HSA-6809953)
0.556
5
UniProt:Q15428 SF3A2
1
SF3A2 [nucleoplasm]
(R-HSA-71964)
0.556
5
UniProt:Q9BYQ3 KRTAP9-3
1
KRTAP9-3 [cytosol]
(R-HSA-6809954)
0.556
3
UniProt:P22301 IL10
1
IL10 [extracellular region]
(R-HSA-447125)
0.556
3
UniProt:P50454 SERPINH1
1
SERPINH1 [endoplasmic reticulum lumen]
(R-HSA-2127480)
0.556
3
UniProt:Q14192 FHL2
1
FHL2 [nucleoplasm]
(R-HSA-561161)
0.556
5
UniProt:P45973 CBX5
2
CBX5 [nucleoplasm]
(R-HSA-994093)
monoSUMO1-K84,K-CBX5 [nucleoplasm]
(R-HSA-4615849)
0.556
3
UniProt:Q9BYJ1 ALOXE3
1
ALOXE3 [cytosol]
(R-HSA-8942204)
0.556
3
UniProt:P37173 TGFBR2
9
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 K128fs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 K128fs*35 [cytosol]
(R-HSA-3642166)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 [plasma membrane]
(R-HSA-170842)
0.556
3
UniProt:Q9H944 MED20
1
MED20 [nucleoplasm]
(R-HSA-212428)
0.556
3
UniProt:Q8CCI5
1
Rybp [nucleoplasm]
(R-MMU-8937975)
0.544
2
UniProt:P78527 PRKDC
4
K48polyUb-PRKDC [cytosol]
(R-HSA-8938766)
PRKDC [cytosol]
(R-HSA-3134816)
PRKDC [nucleoplasm]
(R-HSA-62161)
p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm]
(R-HSA-76302)
0.499
2
UniProt:Q12857 NFIA
1
NFIA [nucleoplasm]
(R-HSA-60134)
0.471
2
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