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CARD8 [cytosol]
Stable Identifier
R-HSA-6805447
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Caspase recruitment domain-containing protein 8, TUCAN, Tumor up-regulated CARD-containing antagonist of CASP9, CARD-inhibitor of NF-kappa-B-activating ligand, Apoptotic protein NDPP1, CARDINAL
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Apoptotic factor-mediated response (Homo sapiens)
Cytochrome c-mediated apoptotic response (Homo sapiens)
Formation of apoptosome (Homo sapiens)
CYCS:APAF1 binds procaspase-9 (Homo sapiens)
CARD8 [cytosol] (Homo sapiens)
Regulation of the apoptosome activity (Homo sapiens)
CARD8 binds CASP9(1-416) (Homo sapiens)
CARD8 [cytosol] (Homo sapiens)
CASP9:CARD [cytosol] (Homo sapiens)
CARD8 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y2G2 CARD8
Gene Names
CARD8, DACAR, KIAA0955, NDPP1
Chain
chain:1-537, chain:1-296, chain:297-537
Reference Genes
COSMIC (genes):CARD8 CARD8
ENSEMBL:ENSG00000105483 CARD8
HGNC:17057 CARD8
UCSC:Q9Y2G2 CARD8
Other Identifiers
11740035_a_at
11740036_at
11746055_a_at
11746906_s_at
11747437_a_at
11747703_x_at
11755070_a_at
11760244_a_at
11761100_s_at
11763365_x_at
1554479_PM_a_at
1554479_a_at
16873880
204950_PM_at
204950_at
228641_3p_at
228641_PM_at
228641_at
22900
232969_PM_at
232969_at
3866957
3866959
3866960
3866961
3866962
3866964
3866966
3866967
3866971
3866972
3866973
3866974
3866975
3866976
3866977
3866978
3866979
3866980
3866981
3866982
3866983
3866988
3866990
3866991
3866992
3866993
3866994
3866995
3866996
3866997
3866998
3866999
3867000
3867001
3867002
3867003
3867004
3867005
3867006
3867007
3867011
3867012
3867016
3867017
3867018
3867019
3867020
3867021
41100_at
42055_at
43059_at
43060_g_at
65265_r_at
8038023
8038029
91036_at
A_21_P0000098
A_23_P27721
A_24_P14260
A_24_P196688
A_32_P800179
GE53621
GO:0002376
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006355
GO:0006508
GO:0006915
GO:0006954
GO:0008233
GO:0008656
GO:0010804
GO:0012501
GO:0016787
GO:0031665
GO:0032088
GO:0032089
GO:0032691
GO:0032731
GO:0032991
GO:0038187
GO:0042803
GO:0042981
GO:0043122
GO:0043124
GO:0043226
GO:0043280
GO:0045087
GO:0050700
GO:0051607
GO:0060089
GO:0060090
GO:0061702
GO:0065003
GO:0072559
GO:0097264
GO:0097340
GO:0098542
GO:0098772
GO:0140096
GO:0140374
GO:0140608
GO:0140633
GO:0140634
GO:0140693
GO:1900226
HMNXSV003001800
HMNXSV003002858
HMNXSV003002989
HMNXSV003023078
HMNXSV003050055
Hs.10031.1.S1_3p_at
Hs.10031.1.S1_3p_s_at
Hs.325662.0.S1_3p_at
Hs2.10031.2.S1_3p_s_at
ILMN_2192281
PH_hs_0026073
TC19001677.hg
TC19002534.hg
g7662403_3p_at
Participates
as a component of
CASP9:CARD [cytosol] (Homo sapiens)
as an input of
CARD8 binds CASP9(1-416) (Homo sapiens)
This entity regulates
Negatively
CYCS:APAF1 binds procaspase-9
(Homo sapiens)
Inferred To
CARD8 [cytosol]
(Canis familiaris)
CARD8 [cytosol]
(Gallus gallus)
pycard [cytosol]
(Danio rerio)
Cross References
OpenTargets
ENSG00000105483
ENSEMBL
ENSP00000427922
,
ENSP00000428883
,
ENSP00000428736
,
ENST00000519940
,
ENST00000520753
,
ENSP00000430747
,
ENSP00000391248
,
ENST00000651546
,
ENST00000520007
,
ENST00000447740
,
ENSP00000430108
,
ENST00000519332
,
ENST00000521613
,
ENST00000391898
,
ENST00000522431
,
ENST00000520015
,
ENSP00000375767
,
ENSP00000429839
,
ENSP00000427727
,
ENSP00000427858
,
ENSP00000499211
,
ENST00000520153
HPA
ENSG00000105483-CARD8
PRO
Q9Y2G2
Pharos - Targets
Q9Y2G2
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75528 TADA3
1
TADA3 [nucleoplasm]
(R-HSA-3322966)
0.527
2
UniProt:O75461 E2F6
2
E2F6 [nucleoplasm]
(R-HSA-8953089)
p-S12-E2F6 [nucleoplasm]
(R-HSA-9007536)
0.527
2
UniProt:Q9ULM3 YEATS2
1
YEATS2 [nucleoplasm]
(R-HSA-3321976)
0.527
2
UniProt:Q9BYE7 PCGF6
1
PCGF6 [nucleoplasm]
(R-HSA-8953572)
0.527
2
UniProt:Q9NYJ8 TAB2
4
TAB2 [cytosol]
(R-HSA-168117)
TAB2 [endosome membrane]
(R-HSA-450279)
TAB2 [plasma membrane]
(R-HSA-168116)
TAB2 [nucleoplasm]
(R-HSA-1253323)
0.527
2
UniProt:Q9Y467 SALL2
0.527
2
UniProt:Q9NWK9 BCD1
0.527
2
UniProt:Q15906 CFL1
1
VPS72 [nucleoplasm]
(R-HSA-3321992)
0.527
2
UniProt:Q96ES7 SGF29
1
SGF29 [nucleoplasm]
(R-HSA-3662279)
0.527
2
UniProt:Q5VUJ6 LRCH2
0.527
2
UniProt:Q8IWI9 MGA
1
MGA [nucleoplasm]
(R-HSA-8953093)
0.527
2
UniProt:Q8TEP8 CEP192
1
CEP192 [cytosol]
(R-HSA-380319)
0.527
2
UniProt:Q5T3J3 LRIF1
0.527
2
UniProt:Q9H792 PEAK1
1
PEAK1 [cytosol]
(R-HSA-9715162)
0.527
2
UniProt:Q9BZG8 DPH1
1
DPH1 [cytosol]
(R-HSA-5358384)
0.527
2
UniProt:Q14192 FHL2
1
FHL2 [nucleoplasm]
(R-HSA-561161)
0.508
2
UniProt:Q9Y2G2 CARD8
1
CARD8 [cytosol]
(R-HSA-6805447)
0.508
2
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