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SPHK1 [cytosol]
Stable Identifier
R-HSA-391267
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Sphingosine kinase 1
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Sphingolipid metabolism (Homo sapiens)
Sphingolipid de novo biosynthesis (Homo sapiens)
SPHK1 phosphorylates sphingoid (Homo sapiens)
SPHK1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Protein folding (Homo sapiens)
Chaperonin-mediated protein folding (Homo sapiens)
Association of TriC/CCT with target proteins during biosynthesis (Homo sapiens)
Association of CCT/TriC with sphingosine kinase 1 (Homo sapiens)
CCT/TRiC:ADP:Sphingosine kinase 1 [cytosol] (Homo sapiens)
SPHK1 [cytosol] (Homo sapiens)
SPHK1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Extra-nuclear estrogen signaling (Homo sapiens)
SPHK1 phosphorylates sphingosine in response to E2 stimulation (Homo sapiens)
SPHK1 [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFR2 mediated cell proliferation (Homo sapiens)
PKC phosphorylates sphingosine kinase 1 (Homo sapiens)
SPHK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NYA1 SPHK1
Gene Names
SPHK1, SK1, SPHK, SPK
Chain
chain:1-384
Reference Genes
BioGPS Gene:8877 SPHK1
COSMIC (genes):SPHK1 SPHK1
CTD Gene:8877 SPHK1
dbSNP Gene:8877 SPHK1
ENSEMBL:ENSG00000176170 SPHK1
HGNC:11240 SPHK1
KEGG:hsa:8877 SPHK1
Monarch:8877 SPHK1
NCBI Gene:8877 SPHK1
OMIM:603730 SPHK1
UCSC:Q9NYA1 SPHK1
Reference Transcript
RefSeq:NM_001142601.2 SPHK1
RefSeq:NM_001142602.2 SPHK1
RefSeq:NM_001355139.2 SPHK1
RefSeq:NM_182965.3 SPHK1
RefSeq:XM_005257766.2 SPHK1
RefSeq:NM_021972.3 SPHK1
Participates
as a component of
CCT/TRiC:ADP:Sphingosine kinase 1 [cytosol] (Homo sapiens)
as an input of
Association of CCT/TriC with sphingosine kinase 1 (Homo sapiens)
PKC phosphorylates sphingosine kinase 1 (Homo sapiens)
Other forms of this molecule
p-S225-SPHK1 [cytosol]
p-S225-SPHK1 [nucleoplasm]
SPHK1 [nucleoplasm]
Inferred To
SPHK1 [cytosol]
(Bos taurus)
SPHK1 [cytosol]
(Canis familiaris)
SPHK1 [cytosol]
(Gallus gallus)
SPHK1 [cytosol]
(Sus scrofa)
sgkC [cytosol]
(Dictyostelium discoideum)
tim54 [cytosol]
(Schizosaccharomyces pombe)
sphk1 [cytosol]
(Xenopus tropicalis)
LCB4 [cytosol]
(Saccharomyces cerevisiae)
Sphk1 [cytosol]
(Mus musculus)
Sphk1 [cytosol]
(Rattus norvegicus)
sphk-1 [cytosol]
(Caenorhabditis elegans)
sgkA [cytosol]
(Dictyostelium discoideum)
LCB5 [cytosol]
(Saccharomyces cerevisiae)
lcb4 [cytosol]
(Schizosaccharomyces pombe)
Homologues of SPHK1 [cytosol]
(Dictyostelium discoideum)
Homologues of SPHK1 [cytosol]
(Saccharomyces cerevisiae)
Homologues of SPHK1 [cytosol]
(Schizosaccharomyces pombe)
TIM54 [cytosol]
(Saccharomyces cerevisiae)
Sk1 [cytosol]
(Drosophila melanogaster)
sgkB [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_001342068.1
,
NP_068807.2
,
NP_001136074.1
,
NP_892010.2
,
XP_005257823.1
,
NP_001136073.1
Guide to Pharmacology - Targets
2204
OpenTargets
ENSG00000176170
ENSEMBL
ENSP00000440970
,
ENST00000592299
,
ENSP00000468547
,
ENST00000545180
,
ENSP00000313681
,
ENST00000590959
,
ENST00000392496
,
ENSG00000176170
,
ENSP00000376285
,
ENSP00000465726
,
ENST00000323374
ZINC - Substances
SPHK1_HUMAN
ZINC - Biogenic
SPHK1_HUMAN
ZINC target
Q9NYA1
PRO
Q9NYA1
PDB
4L02
,
4V24
,
3VZC
,
3VZB
,
3VZD
ZINC - Investigational
SPHK1_HUMAN
ZINC - Metabolites
SPHK1_HUMAN
HPA
ENSG00000176170-SPHK1
GeneCards
SPHK1
Pharos - Targets
Q9NYA1
ZINC - Predictions - Purchasable
SPHK1_HUMAN
HMDB Protein
HMDBP01082
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q2M3C7 SPKAP
0.602
4
UniProt:P68104 EEF1A1
7
EEF1A1 [lysosomal membrane]
(R-HSA-9626022)
EEF1A1 [cytosol]
(R-HSA-156905)
EEF1A1 [secretory granule lumen]
(R-HSA-6801479)
EEF1A1 [extracellular region]
(R-HSA-6806456)
EEF1A1 [ficolin-1-rich granule lumen]
(R-HSA-6801528)
Me3K318-EEF1A1 [cytosol]
(R-HSA-8932419)
Me3K79-EEF1A1 [cytosol]
(R-HSA-8932212)
0.544
2
UniProt:Q14192 FHL2
1
FHL2 [nucleoplasm]
(R-HSA-561161)
0.543
7
UniProt:Q96PQ7 KLHL5
1
KLHL5 [cytosol]
(R-HSA-8863223)
0.482
2
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