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SPHK1
Stable Identifier
R-HSA-391267
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Sphingosine kinase 1
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Sphingolipid metabolism (Homo sapiens)
Sphingolipid de novo biosynthesis (Homo sapiens)
sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Homo sapiens)
SPHK [cytosol] (Homo sapiens)
SPHK1 [cytosol] (Homo sapiens)
sphingosine +ATP => sphingosine 1-phosphate + ADP (Homo sapiens)
SPHK [cytosol] (Homo sapiens)
SPHK1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Protein folding (Homo sapiens)
Chaperonin-mediated protein folding (Homo sapiens)
Association of TriC/CCT with target proteins during biosynthesis (Homo sapiens)
Association of CCT/TriC with sphingosine kinase 1 (Homo sapiens)
CCT/TRiC:ADP:Sphingosine kinase 1 [cytosol] (Homo sapiens)
SPHK1 [cytosol] (Homo sapiens)
SPHK1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFR2 mediated cell proliferation (Homo sapiens)
PKC phosphorylates sphingosine kinase 1 (Homo sapiens)
SPHK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NYA1 SPHK1
Gene Names
SPHK1, SPHK, SPK
Chain
chain:1-384
Reference Genes
BioGPS Gene:8877 SPHK1
COSMIC (genes):SPHK1 SPHK1
CTD Gene:8877 SPHK1
dbSNP Gene:8877 SPHK1
ENSEMBL:ENSG00000176170 SPHK1
HGNC:11240 SPHK1
KEGG Gene (Homo sapiens):hsa:8877 SPHK1
Monarch:8877 SPHK1
NCBI Gene:8877 SPHK1
OMIM:603730 SPHK1
UCSC:Q9NYA1 SPHK1
Reference Transcript
RefSeq:NM_001142602.1 SPHK1
RefSeq:XM_005257766.2 SPHK1
RefSeq:NM_021972.3 SPHK1
RefSeq:NM_182965.2 SPHK1
RefSeq:NM_001142601.1 SPHK1
Other Identifiers
0000380541
0000610138
11755046_a_at
16838059
219257_s_at
22829
28761
3735480
3735481
3735488
3735489
3735490
3735492
3735494
3735495
3735496
3735497
3735498
3735499
3735500
3VZB
3VZC
3VZD
4L02
4V24
51923_at
8010061
8877
A_14_P120136
A_14_P125492
A_23_P38106
A_33_P3222069
CCDS11744
CCDS45785
CCDS59297
ENSG00000176170
ENSP00000313681
ENSP00000376285
ENSP00000440970
ENSP00000465726
ENSP00000468547
ENST00000323374
ENST00000392496
ENST00000545180
ENST00000590959
ENST00000592299
EntrezGene:8877
g11464966_3p_a_at
GE61925
GO:0000166
GO:0000287
GO:0001568
GO:0003376
GO:0003677
GO:0003951
GO:0005515
GO:0005516
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006457
GO:0006670
GO:0006954
GO:0007165
GO:0007420
GO:0008152
GO:0008284
GO:0008481
GO:0010800
GO:0010803
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0017050
GO:0019722
GO:0030148
GO:0030307
GO:0030335
GO:0031398
GO:0032651
GO:0035556
GO:0038036
GO:0042346
GO:0043066
GO:0045766
GO:0045931
GO:0045987
GO:0046512
GO:0046521
GO:0046834
GO:0048146
GO:0051092
GO:0051721
HGNC:11240
HPA022829
HPA028761
Hs.68061
ILMN_1702032
ILMN_1774153
ILMN_2357134
MIM:603730
NM_001142601
NM_001142602
NM_021972
NM_182965
NP_001136073
NP_001136074
NP_001342068
NP_068807
NP_892010
PF00781
PH_hs_0004080
Q53ZR5
SM00046
SPHK1
SPHK1-201
SPHK1-202
SPHK1-203
SPHK1-207
SPHK1-210
TC17000872.hg
uc002jrf.1
uc002jrh.3
uc002jri.2
uc002jrj.3
uc002jrk.4
UPI000003AC26
UPI000006DED4
UPI00001AF3B5
XM_005257766
XP_005257823
Participant Of
input
Association of CCT/TriC with sphingosine kinase 1
PKC phosphorylates sphingosine kinase 1
hasMember
SPHK [cytosol]
hasComponent
CCT/TRiC:ADP:Sphingosine kinase 1 [cytosol]
Other forms of this molecule
p-S225-SPHK1 [cytosol]
Inferred To
SPHK1 [cytosol] (Bos taurus)
SPHK1 [cytosol] (Caenorhabditis elegans)
SPHK1 [cytosol] (Canis familiaris)
SPHK1 [cytosol] (Danio rerio)
SPHK1 [cytosol] (Drosophila melanogaster)
SPHK1 [cytosol] (Gallus gallus)
SPHK1 [cytosol] (Mus musculus)
SPHK1 [cytosol] (Rattus norvegicus)
SPHK1 [cytosol] (Saccharomyces cerevisiae)
SPHK1 [cytosol] (Sus scrofa)
SPHK1 [cytosol] (Taeniopygia guttata)
SPHK1 [cytosol] (Xenopus tropicalis)
Homologues of SPHK1 [cytosol] (Drosophila melanogaster)
Homologues of SPHK1 [cytosol] (Rattus norvegicus)
Homologues of SPHK1 [cytosol] (Saccharomyces cerevisiae)
Homologues of SPHK1 [cytosol] (Taeniopygia guttata)
Cross References
RefSeq
NP_068807.2
,
NP_001136073.1
,
NP_892010.2
,
XP_005257823.1
,
NP_001136074.1
ZINC - Metabolites
SPHK1_HUMAN
Brenda
2.7.1.91
ZINC - Substances
SPHK1_HUMAN
GeneCards
Q9NYA1
DOCK Blaster
4V24
,
3VZB
,
3VZC
,
4L02
,
3VZD
ZINC target
Q9NYA1
ZINC - Biogenic
SPHK1_HUMAN
PRO
Q9NYA1
ZINC - Predictions - Purchasable
SPHK1_HUMAN
PDB
3VZB
,
3VZC
,
3VZD
,
4L02
,
4V24
HMDB Protein
HMDBP01082
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q2M3C7 SPKAP
0.602
4
UniProt:P68104 EEF1A1
6
Me3K318-EEF1A1 [cytosol]
(R-HSA-8932419)
Me3K79-EEF1A1 [cytosol]
(R-HSA-8932212)
EEF1A1 [cytosol]
(R-HSA-156905)
EEF1A1 [secretory granule lumen]
(R-HSA-6801479)
EEF1A1 [extracellular region]
(R-HSA-6806456)
EEF1A1 [ficolin-1-rich granule lumen]
(R-HSA-6801528)
0.544
2
UniProt:Q14192 FHL2
1
FHL2 [nucleoplasm]
(R-HSA-561161)
0.543
7
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