Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
p-S225-SPHK1 [cytosol]
Stable Identifier
R-HSA-5218716
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
PKR-mediated signaling (Homo sapiens)
PKR forms a dimer (Homo sapiens)
EIF2AK2:p-SPHK1 [cytosol] (Homo sapiens)
p-S225-SPHK1 [cytosol] (Homo sapiens)
SPHK1 binds PKR (Homo sapiens)
EIF2AK2:p-SPHK1 [cytosol] (Homo sapiens)
p-S225-SPHK1 [cytosol] (Homo sapiens)
p-S225-SPHK1 [cytosol] (Homo sapiens)
p-S225-SPHK1 localizes to cytosol (Homo sapiens)
p-S225-SPHK1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFR2 mediated cell proliferation (Homo sapiens)
PKC phosphorylates sphingosine kinase 1 (Homo sapiens)
p-S225-SPHK1 [cytosol] (Homo sapiens)
p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Homo sapiens)
p-S225-SPHK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NYA1 SPHK1
Gene Names
SPHK1, SK1, SPHK, SPK
Chain
chain:1-384
Reference Genes
BioGPS Gene:8877 SPHK1
COSMIC (genes):SPHK1 SPHK1
CTD Gene:8877 SPHK1
dbSNP Gene:8877 SPHK1
ENSEMBL:ENSG00000176170 SPHK1
ENSEMBL_homo_sapiens_GENE:ENSG00000176170.14 SPHK1
HGNC:11240 SPHK1
KEGG Gene (Homo sapiens):8877 SPHK1
Monarch:8877 SPHK1
NCBI Gene:8877 SPHK1
OMIM:603730 SPHK1
UCSC:Q9NYA1 SPHK1
Reference Transcript
RefSeq:NM_021972.3 SPHK1
RefSeq:NM_001142601.1 SPHK1
RefSeq:NM_182965.2 SPHK1
RefSeq:XM_005257766.2 SPHK1
RefSeq:NM_001142602.1 SPHK1
Other Identifiers
11755046_a_at
16838059
219257_PM_s_at
219257_s_at
3735479
3735480
3735481
3735488
3735489
3735490
3735491
3735492
3735494
3735495
3735496
3735497
3735498
3735499
3735500
51923_at
8010061
8877
A_14_P120136
A_14_P125492
A_23_P38106
A_33_P3222069
GE61925
GO:0000166
GO:0000278
GO:0000287
GO:0001568
GO:0002376
GO:0003012
GO:0003376
GO:0003677
GO:0003824
GO:0005515
GO:0005516
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005829
GO:0005886
GO:0005905
GO:0006351
GO:0006355
GO:0006473
GO:0006629
GO:0006670
GO:0006954
GO:0007420
GO:0008283
GO:0008284
GO:0008289
GO:0008481
GO:0010008
GO:0010800
GO:0010803
GO:0012501
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016407
GO:0016740
GO:0017050
GO:0019722
GO:0023052
GO:0030100
GO:0030139
GO:0030148
GO:0030307
GO:0030335
GO:0031398
GO:0031410
GO:0031901
GO:0032651
GO:0032740
GO:0034612
GO:0035556
GO:0035924
GO:0036211
GO:0038036
GO:0043066
GO:0043226
GO:0043231
GO:0045202
GO:0045766
GO:0045840
GO:0045931
GO:0045987
GO:0046512
GO:0046521
GO:0048146
GO:0048856
GO:0048870
GO:0050764
GO:0051092
GO:0051721
GO:0060089
GO:0061024
GO:0070301
GO:0071363
GO:0071897
GO:0090520
GO:0098793
GO:0140014
GO:0150077
GO:1900060
GO:1900745
GO:1901224
GO:1903978
GO:1905364
HMNXSV003001592
ILMN_1774153
ILMN_2357134
PH_hs_0004080
TC17000872.hg
g11464966_3p_a_at
Participates
as an input of
SPHK1 binds PKR (Homo sapiens)
as an output of
p-S225-SPHK1 localizes to cytosol (Homo sapiens)
PKC phosphorylates sphingosine kinase 1 (Homo sapiens)
as a component of
EIF2AK2:p-SPHK1 [cytosol] (Homo sapiens)
Other forms of this molecule
SPHK1 [nucleoplasm]
p-S225-SPHK1 [nucleoplasm]
SPHK1 [cytosol]
Inferred To
phospho-Sk1 [cytosol]
(Drosophila melanogaster)
phospho-SPHK1 [cytosol]
(Bos taurus)
phospho-SPHK1 [cytosol]
(Canis familiaris)
phospho-SPHK1 [cytosol]
(Gallus gallus)
phospho-SPHK1 [cytosol]
(Sus scrofa)
phospho-p-S225-SPHK1 [cytosol]
(Caenorhabditis elegans)
phospho-p-S225-SPHK1 [cytosol]
(Dictyostelium discoideum)
phospho-p-S225-SPHK1 [cytosol]
(Mus musculus)
phospho-p-S225-SPHK1 [cytosol]
(Rattus norvegicus)
phospho-p-S225-SPHK1 [cytosol]
(Saccharomyces cerevisiae)
phospho-p-S225-SPHK1 [cytosol]
(Schizosaccharomyces pombe)
Modified Residues
Name
O-phospho-L-serine at 225
Coordinate
225
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_892010.2
,
XP_005257823.1
,
NP_001136073.1
,
NP_068807.2
,
NP_001136074.1
Guide to Pharmacology - Targets
2204
OpenTargets
ENSG00000176170
ZINC - Substances
SPHK1_HUMAN
ZINC target
Q9NYA1
ZINC - Biogenic
SPHK1_HUMAN
PRO
Q9NYA1
PDB
4V24
,
3VZD
,
3VZB
,
3VZC
,
4L02
ZINC - Investigational
SPHK1_HUMAN
ZINC - Metabolites
SPHK1_HUMAN
HPA
ENSG00000176170-SPHK1
GeneCards
Q9NYA1
Ensembl
ENSP00000376285
,
ENST00000590959
,
ENST00000592299
,
ENSG00000176170
,
ENST00000392496
,
ENST00000323374
,
ENSP00000313681
,
ENSP00000465726
,
ENSP00000440970
,
ENST00000545180
,
ENSP00000468547
Pharos - Targets
Q9NYA1
ZINC - Predictions - Purchasable
SPHK1_HUMAN
HMDB Protein
HMDBP01082
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q2M3C7 SPKAP
0.602
4
UniProt:P68104 EEF1A1
7
Me3K79-EEF1A1 [cytosol]
(R-HSA-8932212)
Me3K318-EEF1A1 [cytosol]
(R-HSA-8932419)
EEF1A1 [secretory granule lumen]
(R-HSA-6801479)
EEF1A1 [extracellular region]
(R-HSA-6806456)
EEF1A1 [ficolin-1-rich granule lumen]
(R-HSA-6801528)
EEF1A1 [cytosol]
(R-HSA-156905)
EEF1A1 [lysosomal membrane]
(R-HSA-9626022)
0.544
2
UniProt:Q14192 FHL2
1
FHL2 [nucleoplasm]
(R-HSA-561161)
0.543
7
UniProt:Q96PQ7 KLHL5
1
KLHL5 [cytosol]
(R-HSA-8863223)
0.482
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text