Reactome | monoSUMO1-K601-ZNF131 [nucleoplasm]

monoSUMO1-K601-ZNF131 [nucleoplasm]

Stable Identifier

R-HSA-3296152

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SUMO1 N-glycyl-lys601 ZNF131, Zinc finger protein 131, ZN131_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
22467880	Small ubiquitin-like modifier (SUMO) modification of zinc finger protein 131 potentiates its negative effect on estrogen signaling Oh, Y, Chung, KC	J. Biol. Chem.	2012

External Reference Information

External Reference

UniProt:P52739 ZNF131

Gene Names

ZNF131

Chain

chain:1-623

Reference Genes

BioGPS Gene:7690 ZNF131

COSMIC (genes):ZNF131 ZNF131

CTD Gene:7690 ZNF131

dbSNP Gene:7690 ZNF131

ENSEMBL:ENSG00000172262 ZNF131

HGNC:12915 ZNF131

KEGG:hsa:7690 ZNF131

Monarch:7690 ZNF131

NCBI Gene:7690 ZNF131

OMIM:604073 ZNF131

UCSC:P52739 ZNF131

Reference Transcript

Participates

as an output of

CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Homo sapiens)

Other forms of this molecule

ZNF131 [nucleoplasm]

Inferred To

si:ch211-155e24.3 [nucleoplasm] (Danio rerio)

si:dkey-182i3.10 [nucleoplasm] (Danio rerio)

si:ch211-191d2.2 [nucleoplasm] (Danio rerio)

ZNF131 [nucleoplasm] (Bos taurus)

ZNF131 [nucleoplasm] (Gallus gallus)

znfl2a [nucleoplasm] (Danio rerio)

si:ch73-299h12.6 [nucleoplasm] (Danio rerio)

ztf-3 [nucleoplasm] (Caenorhabditis elegans)

e4f1 [nucleoplasm] (Danio rerio)

zbtb38 [nucleoplasm] (Danio rerio)

Znf131 [nucleoplasm] (Mus musculus)

si:dkeyp-2e4.2 [nucleoplasm] (Danio rerio)

Homologues of monoSUMO1-K601-ZNF131 [nucleoplasm] (Caenorhabditis elegans)

Homologues of monoSUMO1-K601-ZNF131 [nucleoplasm] (Danio rerio)

Zfp131 [nucleoplasm] (Rattus norvegicus)

ztf-27 [nucleoplasm] (Caenorhabditis elegans)

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 601

Coordinate

601

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

XP_016865323.1, XP_005248420.1, NP_003423.1, NP_001284477.1, XP_016865327.1, XP_016865319.1, NP_001375248.1, NP_001317637.1, NP_001317643.1, NP_001317641.1, NP_001317640.1, NP_001317642.1, NP_001317646.1, NP_001317636.1, NP_001317644.1, NP_001317635.1

OpenTargets

ENSG00000172262

ENSEMBL

ENSP00000305804, ENSP00000423945, ENST00000509634, ENSG00000172262, ENSP00000426504, ENSP00000507111, ENST00000682664, ENST00000505606, ENST00000306938, ENSP00000421246, ENST00000509156

HPA

ENSG00000172262-ZNF131

GeneCards

ZNF131

PRO

P52739

Pharos - Targets

P52739

GlyGen

P52739

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.547	3
UniProt:P49336 CDK8	1	CDK8 [nucleoplasm] (R-HSA-212440)	0.483	3

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