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SPHK1 [nucleoplasm]
Stable Identifier
R-HSA-9836616
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Sphingosine kinase 1
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
PKR-mediated signaling (Homo sapiens)
p-PKR dimer phosphorylates SPHK1 (Homo sapiens)
SPHK1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NYA1 SPHK1
Gene Names
SPHK1, SK1, SPHK, SPK
Chain
chain:1-384
Reference Genes
BioGPS Gene:8877 SPHK1
COSMIC (genes):SPHK1 SPHK1
CTD Gene:8877 SPHK1
dbSNP Gene:8877 SPHK1
ENSEMBL:ENSG00000176170 SPHK1
ENSEMBL_homo_sapiens_GENE:ENSG00000176170.14 SPHK1
HGNC:11240 SPHK1
KEGG Gene (Homo sapiens):8877 SPHK1
Monarch:8877 SPHK1
NCBI Gene:8877 SPHK1
OMIM:603730 SPHK1
UCSC:Q9NYA1 SPHK1
Reference Transcript
RefSeq:NM_021972.3 SPHK1
RefSeq:NM_001142601.1 SPHK1
RefSeq:NM_182965.2 SPHK1
RefSeq:XM_005257766.2 SPHK1
RefSeq:NM_001142602.1 SPHK1
Other Identifiers
11755046_a_at
16838059
219257_PM_s_at
219257_s_at
3735479
3735480
3735481
3735488
3735489
3735490
3735491
3735492
3735494
3735495
3735496
3735497
3735498
3735499
3735500
51923_at
8010061
8877
A_14_P120136
A_14_P125492
A_23_P38106
A_33_P3222069
GE61925
GO:0000166
GO:0000278
GO:0000287
GO:0001568
GO:0002376
GO:0003012
GO:0003376
GO:0003677
GO:0003824
GO:0005515
GO:0005516
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005829
GO:0005886
GO:0005905
GO:0006351
GO:0006355
GO:0006473
GO:0006629
GO:0006670
GO:0006954
GO:0007420
GO:0008283
GO:0008284
GO:0008289
GO:0008481
GO:0010008
GO:0010800
GO:0010803
GO:0012501
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016407
GO:0016740
GO:0017050
GO:0019722
GO:0023052
GO:0030100
GO:0030139
GO:0030148
GO:0030307
GO:0030335
GO:0031398
GO:0031410
GO:0031901
GO:0032651
GO:0032740
GO:0034612
GO:0035556
GO:0035924
GO:0036211
GO:0038036
GO:0043066
GO:0043226
GO:0043231
GO:0045202
GO:0045766
GO:0045840
GO:0045931
GO:0045987
GO:0046512
GO:0046521
GO:0048146
GO:0048856
GO:0048870
GO:0050764
GO:0051092
GO:0051721
GO:0060089
GO:0061024
GO:0070301
GO:0071363
GO:0071897
GO:0090520
GO:0098793
GO:0140014
GO:0150077
GO:1900060
GO:1900745
GO:1901224
GO:1903978
GO:1905364
HMNXSV003001592
ILMN_1774153
ILMN_2357134
PH_hs_0004080
TC17000872.hg
g11464966_3p_a_at
Participates
as an input of
p-PKR dimer phosphorylates SPHK1 (Homo sapiens)
Other forms of this molecule
p-S225-SPHK1 [nucleoplasm]
p-S225-SPHK1 [cytosol]
SPHK1 [cytosol]
Inferred To
Sk1 [nucleoplasm]
(Drosophila melanogaster)
SPHK1 [nucleoplasm]
(Bos taurus)
SPHK1 [nucleoplasm]
(Caenorhabditis elegans)
SPHK1 [nucleoplasm]
(Canis familiaris)
SPHK1 [nucleoplasm]
(Dictyostelium discoideum)
SPHK1 [nucleoplasm]
(Gallus gallus)
SPHK1 [nucleoplasm]
(Mus musculus)
SPHK1 [nucleoplasm]
(Rattus norvegicus)
SPHK1 [nucleoplasm]
(Saccharomyces cerevisiae)
SPHK1 [nucleoplasm]
(Schizosaccharomyces pombe)
SPHK1 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_892010.2
,
XP_005257823.1
,
NP_001136073.1
,
NP_068807.2
,
NP_001136074.1
Guide to Pharmacology - Targets
2204
OpenTargets
ENSG00000176170
ZINC - Substances
SPHK1_HUMAN
ZINC target
Q9NYA1
ZINC - Biogenic
SPHK1_HUMAN
PRO
Q9NYA1
PDB
4V24
,
3VZD
,
3VZB
,
3VZC
,
4L02
ZINC - Investigational
SPHK1_HUMAN
ZINC - Metabolites
SPHK1_HUMAN
HPA
ENSG00000176170-SPHK1
GeneCards
Q9NYA1
Ensembl
ENSP00000376285
,
ENST00000590959
,
ENST00000592299
,
ENSG00000176170
,
ENST00000392496
,
ENST00000323374
,
ENSP00000313681
,
ENSP00000465726
,
ENSP00000440970
,
ENST00000545180
,
ENSP00000468547
Pharos - Targets
Q9NYA1
ZINC - Predictions - Purchasable
SPHK1_HUMAN
HMDB Protein
HMDBP01082
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q2M3C7 SPKAP
0.602
4
UniProt:P68104 EEF1A1
7
Me3K79-EEF1A1 [cytosol]
(R-HSA-8932212)
Me3K318-EEF1A1 [cytosol]
(R-HSA-8932419)
EEF1A1 [secretory granule lumen]
(R-HSA-6801479)
EEF1A1 [extracellular region]
(R-HSA-6806456)
EEF1A1 [ficolin-1-rich granule lumen]
(R-HSA-6801528)
EEF1A1 [cytosol]
(R-HSA-156905)
EEF1A1 [lysosomal membrane]
(R-HSA-9626022)
0.544
2
UniProt:Q14192 FHL2
1
FHL2 [nucleoplasm]
(R-HSA-561161)
0.543
7
UniProt:Q96PQ7 KLHL5
1
KLHL5 [cytosol]
(R-HSA-8863223)
0.482
2
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