Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases

Stable Identifier
R-HSA-170153
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases
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Following its translocation to the nucleus, Cdc25 dephosphorylates and activates nuclear cyclin B1:Cdc2 complexes (Strausfeld et al., 1991).
Literature References
PubMed ID Title Journal Year
1828290 Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein

Strausfeld, U, Labbe, JC, Fesquet, D, Cavadore, JC, Picard, A, Sadhu, K, Russell, P, Doree, M

Nature 1991
Participants
Input
Output
Participates
as an event of
Catalyst Activity

phosphoprotein phosphatase activity of CDC25 [nucleoplasm]

Physical Entity
CDC25 [nucleoplasm] (Homo sapiens)
Activity
phosphoprotein phosphatase activity (GO:0004721)
Orthologous Events
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Bos taurus)
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Caenorhabditis elegans)
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Canis familiaris)
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Drosophila melanogaster)
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Mus musculus)
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Rattus norvegicus)
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Sus scrofa)
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Xenopus tropicalis)
Created
Matthews, L  (2005-12-23)
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