Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases

Stable Identifier
R-HSA-170153
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases
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Following its translocation to the nucleus, Cdc25 dephosphorylates and activates nuclear cyclin B1:Cdc2 complexes (Strausfeld et al., 1991).
Literature References
PubMed ID Title Journal Year
1828290 Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein

Doree, M, Cavadore, JC, Picard, A, Fesquet, D, Strausfeld, U, Sadhu, K, Russell, P, Labbe, JC

Nature 1991
Participants
Input
Output
Participates
as an event of
Catalyst Activity

phosphoprotein phosphatase activity of CDC25 [nucleoplasm]

Physical Entity
CDC25 [nucleoplasm] (Homo sapiens)
Activity
phosphoprotein phosphatase activity (GO:0004721)
Orthologous Events
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Bos taurus)
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Caenorhabditis elegans)
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Canis familiaris)
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Drosophila melanogaster)
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Mus musculus)
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Rattus norvegicus)
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Sus scrofa)
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Xenopus tropicalis)
Created
Matthews, L  (2005-12-23)
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