Reactome | PP2A-PP2R5C dephosphorylates MDM2

PP2A-PP2R5C dephosphorylates MDM2

Stable Identifier

R-HSA-6792863

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        PP2A-PP2R5C dephosphorylates MDM2 (Homo sapiens)

General

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The protein serine/threonine phosphatase complex PP2A, recruited to MDM2 through interaction of the PP2A regulatory subunit PPP2R5C and cyclin G1 (CCNG1) dephosphorylates MDM2 on threonine residue T218 (T218 in human MDM2 corresponds to T216 in mouse Mdm2). Dephosphorylation of T218 increases the affinity of MDM2 for TP53 (p53), leading to p53 down-regulation (Okamoto et al. 2002).

CCNG1-recruited PP2A can also dephosphorylate serine residue S166 of human MDM2 (Okamoto et al. 2002).

Literature References