Reactome | NUDT16 hydrolyses IDP to IMP

NUDT16 hydrolyses IDP to IMP

Stable Identifier

R-HSA-2509816

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

IDP + H2O => IMP + phosphate + H(+)

ReviewStatus

5/5

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NUDT16 dimer catalyzes the reaction of IDP and water to form IMP and Pi (orthophosphate). Mg++ is required for enzymatic activity. The protein is mostly located in the nucleus and concentrated in the nucleolus, where it can also mediate the decapping of U8 small nucleolar RNA (Iyama et al. 2010; Peculis et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
20385596	NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest Iyama, T, Abolhassani, N, Tsuchimoto, D, Nonaka, M, Nakabeppu, Y	Nucleic Acids Res.	2010
17567574	Metal determines efficiency and substrate specificity of the nuclear NUDIX decapping proteins X29 and H29K (Nudt16) Peculis, BA, Reynolds, K, Cleland, M	J. Biol. Chem.	2007