NUDT16 hydrolyses IDP to IMP

Stable Identifier
R-HSA-2509816
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
IDP + H2O => IMP + Pi
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NUDT16 hydrolyses IDP to IMP
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NUDT16 dimer catalyzes the reaction of IDP and water to form IMP and Pi (orthophosphate). Mg++ is required for enzymatic activity. The protein is mostly located in the nucleus and concentrated in the nucleolus, where it can also mediate the decapping of U8 small nucleolar RNA (Iyama et al. 2010; Peculis et al. 2007).

Literature References
PubMed ID Title Journal Year
17567574 Metal determines efficiency and substrate specificity of the nuclear NUDIX decapping proteins X29 and H29K (Nudt16)

Peculis, BA, Reynolds, K, Cleland, M

J. Biol. Chem. 2007
20385596 NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

Iyama, T, Abolhassani, N, Tsuchimoto, D, Nonaka, M, Nakabeppu, Y

Nucleic Acids Res. 2010
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
IDP phosphatase activity of NUDT16 dimer [nucleoplasm]
Physical Entity
NUDT16 dimer [nucleoplasm]
Activity
IDP phosphatase activity (1990003)
This event is regulated
Requirements
Orthologous Events
NUDT16 hydrolyses IDP to IMP (Bos taurus)
NUDT16 hydrolyses IDP to IMP (Canis familiaris)
NUDT16 hydrolyses IDP to IMP (Danio rerio)
NUDT16 hydrolyses IDP to IMP (Gallus gallus)
NUDT16 hydrolyses IDP to IMP (Mus musculus)
NUDT16 hydrolyses IDP to IMP (Rattus norvegicus)
NUDT16 hydrolyses IDP to IMP (Sus scrofa)
NUDT16 hydrolyses IDP to IMP (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2012-10-05)
Reviewed
Ito, R  (2012-10-05)
Created
D'Eustachio, P  (2012-10-05)