NUDT16 hydrolyses IDP to IMP

Stable Identifier
R-HSA-2509816
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
IDP + H2O => IMP + Pi
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NUDT16 dimer catalyzes the reaction of IDP and water to form IMP and Pi (orthophosphate). Mg++ is required for enzymatic activity. The protein is mostly located in the nucleus and concentrated in the nucleolus, where it can also mediate the decapping of U8 small nucleolar RNA (Iyama et al. 2010; Peculis et al. 2007).

Literature References
PubMed ID Title Journal Year
17567574 Metal determines efficiency and substrate specificity of the nuclear NUDIX decapping proteins X29 and H29K (Nudt16)

Peculis, BA, Reynolds, K, Cleland, M

J. Biol. Chem. 2007
20385596 NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

Iyama, T, Abolhassani, N, Tsuchimoto, D, Nonaka, M, Nakabeppu, Y

Nucleic Acids Res. 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
IDP phosphatase activity of NUDT16 dimer [nucleoplasm]
Physical Entity
Activity
This event is regulated
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created