NUDT16 dimer catalyzes the reaction of IDP and water to form IMP and Pi (orthophosphate). Mg++ is required for enzymatic activity. The protein is mostly located in the nucleus and concentrated in the nucleolus, where it can also mediate the decapping of U8 small nucleolar RNA (Iyama et al. 2010; Peculis et al. 2007).
Iyama, T, Nakabeppu, Y, Abolhassani, N, Nonaka, M, Tsuchimoto, D
Peculis, BA, Cleland, M, Reynolds, K
inosine-diphosphatase activity of NUDT16 dimer [nucleoplasm]
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