ERKs are inactivated by dual-specific phosphatases (DUSPs)

Stable Identifier
R-HSA-203797
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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ERKs are inactivated by dual-specific phosphatases (DUSPs)
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Over 10 dual specificity phosphatases (DUSPs) active on MAP kinases are known. Among them, some possess good ERK docking sites and so are more specific for the ERKS (DUSP 3, 4, 6, 7), others are more specific for p38MAPK (DUSP1 and 10), while others do not seem to discriminate. It is noteworthy that transcription of DUSP genes is induced by growth factor signaling itself, so that these phosphatases provide feedback attenuation of signaling. Moreover, differential activation of DUSPs by different stimuli is thought to contribute to pathway specificity.

Literature References
PubMed ID Title Journal Year
17322878 A module of negative feedback regulators defines growth factor signaling

Amit, I, Citri, A, Shay, T, Lu, Y, Katz, M, Zhang, F, Tarcic, G, Siwak, D, Lahad, J, Jacob-Hirsch, J, Amariglio, N, Vaisman, N, Segal, E, Rechavi, G, Alon, U, Mills, GB, Domany, E, Yarden, Y

Nat Genet 2007
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine phosphatase activity of ERK-specific DUSP [nucleoplasm]
Physical Entity
ERK-specific DUSP [nucleoplasm]
Activity
protein tyrosine phosphatase activity (0004725)
This event is regulated
Negatively by
Orthologous Events
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ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
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ERKs are inactivated by dual-specific phosphatases (DUSPs) (Rattus norvegicus)
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Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Created
Jassal, B  (2007-11-16)
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