ERKs are inactivated by dual-specific phosphatases (DUSPs)

Stable Identifier
Homo sapiens
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Over 10 dual specificity phosphatases (DUSPs) active on MAP kinases are known. Among them, some possess good ERK docking sites and so are more specific for the ERKS (DUSP 3, 4, 6, 7), others are more specific for p38MAPK (DUSP1 and 10), while others do not seem to discriminate. It is noteworthy that transcription of DUSP genes is induced by growth factor signaling itself, so that these phosphatases provide feedback attenuation of signaling. Moreover, differential activation of DUSPs by different stimuli is thought to contribute to pathway specificity.

Literature References
PubMed ID Title Journal Year
17322878 A module of negative feedback regulators defines growth factor signaling

Siwak, D, Jacob-Hirsch, J, Lu, Y, Amit, I, Tarcic, G, Segal, E, Zhang, F, Shay, T, Vaisman, N, Yarden, Y, Domany, E, Amariglio, N, Mills, GB, Alon, U, Rechavi, G, Katz, M, Lahad, J, Citri, A

Nat Genet 2007
Catalyst Activity

protein tyrosine phosphatase activity of ERK-specific DUSP [nucleoplasm]

This event is regulated
Negatively by
Orthologous Events
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