Reactome | LPIN catalyzes conversion of phosphatidic acid to diacylglycerol

LPIN catalyzes conversion of phosphatidic acid to diacylglycerol

Stable Identifier

R-HSA-5221130

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nuclear envelope, nucleoplasm

Synonyms

1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

LPIN catalyzes conversion of phosphatidic acid to diacylglycerol

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Lipin proteins LPIN1, 2, and 3, associated with the nuclear envelope, can each catalyze the hydrolysis of phosphatidate to yield 1,2-diacyl-glycerol and orthophosphate. The activities of LPIN1 and LPIN2 have been established experimentally (Grimsey et al. 2008); that of LPIN3 is inferred from its structural similarities both to its human paralogues and to its mouse ortholog (Donkor et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
18694939	Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2 O'Hara, L, Rochford, JJ, Carman, GM, Grimsey, N, Siniossoglou, S, Han, GS	J Biol Chem	2008
17158099	Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns Dewald, J, Reue, K, Donkor, J, Sariahmetoglu, M, Brindley, DN	J Biol Chem	2007