PTPN11 dephosphorylates RUNX1

Stable Identifier
R-HSA-8937767
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PTPN11 dephosphorylates RUNX1
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Based on mouse studies, PTPN11 (SHP2) protein tyrosine phosphatase dephosphorylates SRC-phosphorylated RUNX1 (Huang et al. 2012).
Literature References
PubMed ID Title Journal Year
22759635 A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation

Huang, H, Woo, AJ, Waldon, Z, Schindler, Y, Moran, TB, Zhu, HH, Feng, GS, Steen, H, Cantor, AB

Genes Dev. 2012
Participants
Input
Output
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as an event of
Catalyst Activity

protein tyrosine phosphatase activity of p-7Y-RUNX1:PTPN11 [nucleoplasm]

Physical Entity
p-7Y-RUNX1:PTPN11 [nucleoplasm] (Homo sapiens)
Activity
protein tyrosine phosphatase activity (GO:0004725)
Orthologous Events
PTPN11 dephosphorylates RUNX1 (Bos taurus)
PTPN11 dephosphorylates RUNX1 (Canis familiaris)
PTPN11 dephosphorylates RUNX1 (Gallus gallus)
PTPN11 dephosphorylates RUNX1 (Mus musculus)
PTPN11 dephosphorylates RUNX1 (Rattus norvegicus)
PTPN11 dephosphorylates RUNX1 (Sus scrofa)
PTPN11 dephosphorylates RUNX1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Ito, Y  (2016-12-20)
Chuang, LS  (2016-12-20)
Created
Orlic-Milacic, M  (2016-09-06)
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