PTPN11 dephosphorylates RUNX1

Stable Identifier
R-HSA-8937767
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Based on mouse studies, PTPN11 (SHP2) protein tyrosine phosphatase dephosphorylates SRC-phosphorylated RUNX1 (Huang et al. 2012).

Literature References
PubMed ID Title Journal Year
22759635 A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation

Huang, H, Woo, AJ, Waldon, Z, Schindler, Y, Moran, TB, Zhu, HH, Feng, GS, Steen, H, Cantor, AB

Genes Dev. 2012
Participants
Participates
Catalyst Activity

protein tyrosine phosphatase activity of p-7Y-RUNX1:PTPN11 [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
Cite Us!