PP2A mediated localization of RB1 protein in chromatin

Stable Identifier
Reaction [transition]
Homo sapiens
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Dephoshorylation of RB1 by the PP2A complex containing the regulatory subunit PPP2R3B (PR70) (Magenta et al. 2008) is needed for loading of RB1 to the DNA damage sites during S phase of the cell cycle. RB1 suppresses replication of damaged DNA during S phase (Knudsen et al. 2000, Avni et al. 2003).
Literature References
PubMed ID Title Journal Year
14527418 Active localization of the retinoblastoma protein in chromatin and its response to S phase DNA damage.

Livingston, DM, Ganesan, S, Scully, R, Hofmann, F, ElShamy, WM, Yang, H, Martelli, F, Avni, D

Mol Cell 2003
11003670 RB-dependent S-phase response to DNA damage

Knudsen, KE, Wang, JY, Naderi, S, Sever-Chroneos, Z, Feramisco, JR, Hunton, IC, Knudsen, ES, Booth, D, Fribourg, AF

Mol. Cell. Biol. 2000
17991896 Protein phosphatase 2A subunit PR70 interacts with pRb and mediates its dephosphorylation

Capogrossi, MC, Martelli, F, Fasanaro, P, Di Stefano, V, Romani, S, Magenta, A

Mol Cell Biol 2008
Catalyst Activity

phosphoprotein phosphatase activity of PP2A [nucleoplasm]

Orthologous Events
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