Reactome | PP2A mediated localization of RB1 protein in chromatin

PP2A mediated localization of RB1 protein in chromatin

Stable Identifier

R-HSA-113503

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1 phase and G1/S transition (Homo sapiens)
    - G1/S Transition (Homo sapiens)
      - E2F mediated regulation of DNA replication (Homo sapiens)
        
        Inhibition of replication initiation of damaged DNA by RB1/E2F1 (Homo sapiens)
        
        PP2A mediated localization of RB1 protein in chromatin (Homo sapiens)

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PP2A mediated localization of RB1 protein in chromatin

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Dephoshorylation of RB1 by the PP2A complex containing the regulatory subunit PPP2R3B (PR70) (Magenta et al. 2008) is needed for loading of RB1 to the DNA damage sites during S phase of the cell cycle. RB1 suppresses replication of damaged DNA during S phase (Knudsen et al. 2000, Avni et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
14527418	Active localization of the retinoblastoma protein in chromatin and its response to S phase DNA damage. Livingston, DM, Ganesan, S, Scully, R, Hofmann, F, ElShamy, WM, Yang, H, Martelli, F, Avni, D	Mol Cell	2003
11003670	RB-dependent S-phase response to DNA damage Knudsen, KE, Wang, JY, Naderi, S, Sever-Chroneos, Z, Feramisco, JR, Hunton, IC, Knudsen, ES, Booth, D, Fribourg, AF	Mol. Cell. Biol.	2000
17991896	Protein phosphatase 2A subunit PR70 interacts with pRb and mediates its dephosphorylation Capogrossi, MC, Martelli, F, Fasanaro, P, Di Stefano, V, Romani, S, Magenta, A	Mol Cell Biol	2008