PP2A mediated localization of RB1 protein in chromatin

Stable Identifier
R-HSA-113503
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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General
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Dephoshorylation of RB1 by the PP2A complex containing the regulatory subunit PPP2R3B (PR70) (Magenta et al. 2008) is needed for loading of RB1 to the DNA damage sites during S phase of the cell cycle. RB1 suppresses replication of damaged DNA during S phase (Knudsen et al. 2000, Avni et al. 2003).

Literature References
PubMed ID Title Journal Year
11003670 RB-dependent S-phase response to DNA damage

Knudsen, KE, Booth, D, Naderi, S, Sever-Chroneos, Z, Fribourg, AF, Hunton, IC, Feramisco, JR, Wang, JY, Knudsen, ES

Mol. Cell. Biol. 2000
14527418 Active localization of the retinoblastoma protein in chromatin and its response to S phase DNA damage.

Avni, D, Yang, H, Martelli, F, Hofmann, F, ElShamy, WM, Ganesan, S, Scully, R, Livingston, DM

Mol Cell 2003
17991896 Protein phosphatase 2A subunit PR70 interacts with pRb and mediates its dephosphorylation

Magenta, A, Fasanaro, P, Romani, S, Di Stefano, V, Capogrossi, MC, Martelli, F

Mol Cell Biol 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphoprotein phosphatase activity of PP2A [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Created
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