Reactome | PP2A mediated localization of RB1 protein in chromatin

PP2A mediated localization of RB1 protein in chromatin

Stable Identifier

R-HSA-113503

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1 phase and G1/S transition (Homo sapiens)
    - G1/S Transition (Homo sapiens)
      - E2F mediated regulation of DNA replication (Homo sapiens)
        
        Inhibition of replication initiation of damaged DNA by RB1/E2F1 (Homo sapiens)
        
        PP2A mediated localization of RB1 protein in chromatin (Homo sapiens)

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PP2A mediated localization of RB1 protein in chromatin

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Dephoshorylation of RB1 by the PP2A complex containing the regulatory subunit PPP2R3B (PR70) (Magenta et al. 2008) is needed for loading of RB1 to the DNA damage sites during S phase of the cell cycle. RB1 suppresses replication of damaged DNA during S phase (Knudsen et al. 2000, Avni et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
17991896	Protein phosphatase 2A subunit PR70 interacts with pRb and mediates its dephosphorylation Capogrossi, MC, Martelli, F, Fasanaro, P, Di Stefano, V, Romani, S, Magenta, A	Mol Cell Biol	2008
11003670	RB-dependent S-phase response to DNA damage Knudsen, KE, Wang, JY, Naderi, S, Sever-Chroneos, Z, Feramisco, JR, Hunton, IC, Knudsen, ES, Booth, D, Fribourg, AF	Mol. Cell. Biol.	2000
14527418	Active localization of the retinoblastoma protein in chromatin and its response to S phase DNA damage. Livingston, DM, Ganesan, S, Scully, R, Hofmann, F, ElShamy, WM, Yang, H, Martelli, F, Avni, D	Mol Cell	2003