Dephoshorylation of RB1 by the PP2A complex containing the regulatory subunit PPP2R3B (PR70) (Magenta et al. 2008) is needed for loading of RB1 to the DNA damage sites during S phase of the cell cycle. RB1 suppresses replication of damaged DNA during S phase (Knudsen et al. 2000, Avni et al. 2003).
Livingston, DM, Ganesan, S, Scully, R, Hofmann, F, ElShamy, WM, Yang, H, Martelli, F, Avni, D
Knudsen, KE, Wang, JY, Naderi, S, Sever-Chroneos, Z, Feramisco, JR, Hunton, IC, Knudsen, ES, Booth, D, Fribourg, AF
Capogrossi, MC, Martelli, F, Fasanaro, P, Di Stefano, V, Romani, S, Magenta, A
phosphoprotein phosphatase activity of PP2A [nucleoplasm]
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