NUDT16 dimer catalyzes the reaction of dIDP and water to form dIMP and Pi (orthophosphate). Mg++ is required for enzymatic activity. The protein is mostly located in the nucleus and concentrated in the nucleolus, where it can also mediate the decapping of U8 small nucleolar RNA (Iyama et al. 2010; Peculis et al. 2007).
Iyama, T, Nakabeppu, Y, Abolhassani, N, Nonaka, M, Tsuchimoto, D
Peculis, BA, Cleland, M, Reynolds, K
dIDP diphosphatase activity of NUDT16 dimer [nucleoplasm]
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