NUDT16 hydrolyses dIDP to dIMP

Stable Identifier
R-HSA-2509793
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
dIDP + H2O => dIMP + Pi
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NUDT16 hydrolyses dIDP to dIMP
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NUDT16 dimer catalyzes the reaction of dIDP and water to form dIMP and Pi (orthophosphate). Mg++ is required for enzymatic activity. The protein is mostly located in the nucleus and concentrated in the nucleolus, where it can also mediate the decapping of U8 small nucleolar RNA (Iyama et al. 2010; Peculis et al. 2007).

Literature References
PubMed ID Title Journal Year
17567574 Metal determines efficiency and substrate specificity of the nuclear NUDIX decapping proteins X29 and H29K (Nudt16)

Peculis, BA, Reynolds, K, Cleland, M

J. Biol. Chem. 2007
20385596 NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

Iyama, T, Abolhassani, N, Tsuchimoto, D, Nonaka, M, Nakabeppu, Y

Nucleic Acids Res. 2010
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
dIDP diphosphatase activity of NUDT16 dimer [nucleoplasm]
Physical Entity
NUDT16 dimer [nucleoplasm]
Activity
dIDP diphosphatase activity (0097383)
This event is regulated
Requirements
Orthologous Events
NUDT16 hydrolyses dIDP to dIMP (Bos taurus)
NUDT16 hydrolyses dIDP to dIMP (Canis familiaris)
NUDT16 hydrolyses dIDP to dIMP (Danio rerio)
NUDT16 hydrolyses dIDP to dIMP (Gallus gallus)
NUDT16 hydrolyses dIDP to dIMP (Mus musculus)
NUDT16 hydrolyses dIDP to dIMP (Rattus norvegicus)
NUDT16 hydrolyses dIDP to dIMP (Sus scrofa)
NUDT16 hydrolyses dIDP to dIMP (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2012-10-05)
Reviewed
Ito, R  (2012-10-05)
Created
D'Eustachio, P  (2012-10-05)