PPP5C dephosphorylates TP53BP1

Stable Identifier
R-HSA-5683405
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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PPP5C-mediated dephosphorylation of TP53BP1 serine residues S25 and S1778 contributes to dissociation of TP53BP1 from DNA doubles strand break (DSB) sites and termination of DSB repair (Kang et al. 2009).
Literature References
PubMed ID Title Journal Year
19176521 Protein phosphatase 5 regulates the function of 53BP1 after neocarzinostatin-induced DNA damage

Kang, Y, Lee, JH, Hoan, NN, You, HJ, Chang, IY, Sohn, HM

J. Biol. Chem. 2009
Participants
Participates
Catalyst Activity

protein serine/threonine phosphatase activity of PPP5C [nucleoplasm]

Orthologous Events
Authored
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