PPP5C dephosphorylates TP53BP1

Stable Identifier
R-HSA-5683405
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PPP5C dephosphorylates TP53BP1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PPP5C-mediated dephosphorylation of TP53BP1 serine residues S25 and S1778 contributes to dissociation of TP53BP1 from DNA doubles strand break (DSB) sites and termination of DSB repair (Kang et al. 2009).

Literature References
PubMed ID Title Journal Year
19176521 Protein phosphatase 5 regulates the function of 53BP1 after neocarzinostatin-induced DNA damage

Kang, Y, Lee, JH, Hoan, NN, You, HJ, Chang, IY, Sohn, HM

J. Biol. Chem. 2009
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine phosphatase activity of PPP5C [nucleoplasm]

Physical Entity
PPP5C [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine phosphatase activity (GO:0004722)
Orthologous Events
PPP5C dephosphorylates TP53BP1 (Bos taurus)
PPP5C dephosphorylates TP53BP1 (Canis familiaris)
PPP5C dephosphorylates TP53BP1 (Danio rerio)
PPP5C dephosphorylates TP53BP1 (Mus musculus)
PPP5C dephosphorylates TP53BP1 (Rattus norvegicus)
PPP5C dephosphorylates TP53BP1 (Sus scrofa)
PPP5C dephosphorylates TP53BP1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-05-12)
Reviewed
Borowiec, JA  (2015-06-12)
Created
Orlic-Milacic, M  (2015-03-13)
Cite Us!