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Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene
Stable Identifier
R-HSA-6814554
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA polymerase II transcribes snRNA genes (Homo sapiens)
Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
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Like RNA polymerase II at mRNA-encoding genes, RNA polymerase II at snRNA genes is believed to be dephosphorylated at the C-terminal domain (CTD) in order to begin another round of transcription. RNA polymerase II and factors bound to its C-terminal domain (CTD) dissociate and RNA polymerase II dissociates from the 3' end of the snRNA gene. The order of events is unclear.
Participants
Input
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm]
(Homo sapiens)
Output
Initiation factors:CDK7:snRNA gene [nucleoplasm]
(Homo sapiens)
Integrator [nucleoplasm]
(Homo sapiens)
LEC [nucleoplasm]
(Homo sapiens)
x 12
Pi [nucleoplasm]
RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm]
(Homo sapiens)
RPAP2 [nucleoplasm]
(Homo sapiens)
RPRD1A,B:RPRD1A,B [nucleoplasm]
(Homo sapiens)
RPRD2 [nucleoplasm]
(Homo sapiens)
Participates
as an event of
RNA polymerase II transcribes snRNA genes (Homo sapiens)
Inferred From
Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Homo sapiens)
Authored
May, B (2015-11-21)
Reviewed
Hernandez, N (2016-02-19)
Created
May, B (2015-11-27)
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