Dephosphorylation of p107 (RBL1) by PP2A complex containing either PPP2R3B (B" beta) or PPP2R2A (B alpha) regulatory subunit plays a role in maintaining the equilibrium of hyperphosphorylated and hypophosphorylated p107 (RBL1), through counteracting action of cyclin dependent kinases (CDKs) throughout the cell cycle. It is assumed that PP2A dephosphorylates p107 (RBL1) on all four phosphorylation sites, but further experiments are needed to confirm this.
Haines, DS, Grana, X, Davis, AJ, Garriga, J, Jayadeva, G, Sotillo, E, Mumby, M, Kurimchak, A
phosphoprotein phosphatase activity of PP2A [nucleoplasm]
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