Reactome | Dephosphorylation of p107 (RBL1) by PP2A

Dephosphorylation of p107 (RBL1) by PP2A

Stable Identifier

R-HSA-1363274

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Dephosphorylation of p107 by PP2A

ReviewStatus

5/5

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Dephosphorylation of p107 (RBL1) by PP2A complex containing either PPP2R3B (B" beta) or PPP2R2A (B alpha) regulatory subunit plays a role in maintaining the equilibrium of hyperphosphorylated and hypophosphorylated p107 (RBL1), through counteracting action of cyclin dependent kinases (CDKs) throughout the cell cycle. It is assumed that PP2A dephosphorylates p107 (RBL1) on all four phosphorylation sites, but further experiments are needed to confirm this.

Literature References

PubMed ID	Title	Journal	Year
20663872	B55alpha PP2A holoenzymes modulate the phosphorylation status of the retinoblastoma-related protein p107 and its activation Haines, DS, Grana, X, Davis, AJ, Garriga, J, Jayadeva, G, Sotillo, E, Mumby, M, Kurimchak, A	J Biol Chem	2010