Reactome | HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm

HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm

Stable Identifier

R-HSA-5251955

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm

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Protein Hikeshi (C11orf73) is a nuclear import carrier protein for heat-shock 70 proteins (HSP70s) in response to heat-shock stress. It is only able to bind HSP70s when they are bound to ATP. DnaJ homolog subfamily members (aka heat-shock 40 proteins, HSP40s) also translocate to the nucleus under heat-shock stress (Hattori et al. 1992) and can act as stimulators of intrinsic ATPase activity of HSP70s. The result is that Hikeshi dissociates from HSP70:ADP.

Literature References

PubMed ID	Title	Journal	Year
1586970	Intracellular localization and partial amino acid sequence of a stress-inducible 40-kDa protein in HeLa cells Hattori, H, Tanabe, K, Kobayashi, T, Ohtsuka, K, Kaneda, T, Ueda, M, Liu, YC, Tohnai, I	Cell Struct. Funct.	1992