PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus

Stable Identifier
R-HSA-6810410
Type
Reaction
Species
Homo sapiens
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Translocation of TMEM55B (type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase) to the nucleus under conditions of cellular stress leads to dephosphorylation of nuclear PI(4,5)P2 to PI5P, thus increasing the concentration of PI5P in the nucleus (Zou et al. 2007). PIP2 and its derivatives are not associated with nuclear envelope structures (Bornenkov et al. 1998) but localize to poorly defined subnuclear compartments called nuclear specks (reviewed by Barlow et al. 2010).

Literature References
PubMed ID Title Journal Year
17940011 Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis

Marjanovic, J, Majerus, PW, Kisseleva, MV, Wilson, M, Zou, J

Proc. Natl. Acad. Sci. U.S.A. 2007
Participants
Participates
Catalyst Activity

phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity of TMEM55B [nucleoplasm]

Orthologous Events
Cross References
Rhea
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