Dephosphorylation of p130 (RBL2) by PP2A complex containing either PPP2R3B (B" beta) or PPP2R2A (B alpha) regulatory subunit plays a role in maintaining the equilibrium of hyperphosphorylated and hypophosphorylated p130 (RBL2), through counteracting action of cyclin dependent kinases (CDKs). It is assumed that PP2A dephosphorylates p130 (RBL2) on all three phosphorylation sites, but further experiments are needed to confirm this.
Haines, DS, Grana, X, Davis, AJ, Garriga, J, Jayadeva, G, Sotillo, E, Mumby, M, Kurimchak, A
phosphoprotein phosphatase activity of PP2A [nucleoplasm]
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