The protein serine/threonine phosphatase complex composed of a catalytic subunit PPP4C (PP4C) and a regulatory subunit PPP4R2 (PP4R2) dephosphorylates serine S33 of the RPA2 subunit of the RPA heterotrimer. By regulating the availability of unphosphorylated RPA2, PPP4C:PPP4R2 phosphatase regulates the progression of the homologous recombination repair of DNA double strand breaks and the duration of ATR checkpoint signaling (Lee et al. 2010).
Lee, DH, Pan, Y, Kanner, S, Sung, P, Borowiec, JA, Chowdhury, D
© 2021 Reactome