PPP4C:PPP4R2 dephosphorylates RPA2

Stable Identifier
R-HSA-5687758
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PPP4C:PPP4R2 dephosphorylates RPA2
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The protein serine/threonine phosphatase complex composed of a catalytic subunit PPP4C (PP4C) and a regulatory subunit PPP4R2 (PP4R2) dephosphorylates serine S33 of the RPA2 subunit of the RPA heterotrimer. By regulating the availability of unphosphorylated RPA2, PPP4C:PPP4R2 phosphatase regulates the progression of the homologous recombination repair of DNA double-strand breaks and the duration of ATR checkpoint signaling (Lee et al. 2010).
Literature References
PubMed ID Title Journal Year
20154705 A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination

Lee, DH, Pan, Y, Kanner, S, Sung, P, Borowiec, JA, Chowdhury, D

Nat. Struct. Mol. Biol. 2010
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Catalyst Activity

protein serine/threonine phosphatase activity of PPP4C:PPP4R2 [nucleoplasm]

Physical Entity
PPP4C:PPP4R2 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine phosphatase activity (GO:0004722)
Orthologous Events
PPP4C:PPP4R2 dephosphorylates RPA2 (Bos taurus)
PPP4C:PPP4R2 dephosphorylates RPA2 (Canis familiaris)
PPP4C:PPP4R2 dephosphorylates RPA2 (Danio rerio)
PPP4C:PPP4R2 dephosphorylates RPA2 (Mus musculus)
PPP4C:PPP4R2 dephosphorylates RPA2 (Rattus norvegicus)
PPP4C:PPP4R2 dephosphorylates RPA2 (Sus scrofa)
Authored
Orlic-Milacic, M  (2015-05-12)
Reviewed
Borowiec, JA  (2015-06-12)
Created
Orlic-Milacic, M  (2015-04-08)
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