Reactome | PPP4C:PPP4R2 dephosphorylates RPA2

PPP4C:PPP4R2 dephosphorylates RPA2

Stable Identifier

R-HSA-5687758

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

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The protein serine/threonine phosphatase complex composed of a catalytic subunit PPP4C (PP4C) and a regulatory subunit PPP4R2 (PP4R2) dephosphorylates serine S33 of the RPA2 subunit of the RPA heterotrimer. By regulating the availability of unphosphorylated RPA2, PPP4C:PPP4R2 phosphatase regulates the progression of the homologous recombination repair of DNA double strand breaks and the duration of ATR checkpoint signaling (Lee et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20154705	A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination Lee, DH, Pan, Y, Kanner, S, Sung, P, Borowiec, JA, Chowdhury, D	Nat. Struct. Mol. Biol.	2010