The protein serine/threonine phosphatase complex composed of a catalytic subunit PPP4C (PP4C) and a regulatory subunit PPP4R2 (PP4R2) dephosphorylates serine S33 of the RPA2 subunit of the RPA heterotrimer. By regulating the availability of unphosphorylated RPA2, PPP4C:PPP4R2 phosphatase regulates the progression of the homologous recombination repair of DNA double-strand breaks and the duration of ATR checkpoint signaling (Lee et al. 2010).
Lee, DH, Borowiec, JA, Chowdhury, D, Pan, Y, Kanner, S, Sung, P
protein serine/threonine phosphatase activity of PPP4C:PPP4R2 [nucleoplasm]
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