PP2A-PPP2R2A dephosphorylates FOXM1

Stable Identifier
R-HSA-4088141
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PP2A-PPP2R2A dephosphorylates FOXM1
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FOXM1 can bind the regulatory subunit B55-alpha (PPP2R2A) of serine/threonine-protein phosphatase 2A (PP2A). PP2A dephosphorylates FOXM1, preventing its premature activation (Alvarez-Fernandez et al. 2011).

Literature References
PubMed ID Title Journal Year
21813648 Protein phosphatase 2A (B55?) prevents premature activation of forkhead transcription factor FoxM1 by antagonizing cyclin A/cyclin-dependent kinase-mediated phosphorylation

Alvarez-Fernández, M, Medema, RH, Laoukili, J, Halim, VA, Aprelia, M, Mohammed, S

J. Biol. Chem. 2011
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Output
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as an event of
Catalyst Activity

protein serine/threonine phosphatase activity of PP2A-PPP2R2A [nucleoplasm]

Physical Entity
PP2A-PPP2R2A [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine phosphatase activity (GO:0004722)
Orthologous Events
PP2A-PPP2R2A dephosphorylates FOXM1 (Bos taurus)
PP2A-PPP2R2A dephosphorylates FOXM1 (Canis familiaris)
PP2A-PPP2R2A dephosphorylates FOXM1 (Danio rerio)
PP2A-PPP2R2A dephosphorylates FOXM1 (Mus musculus)
PP2A-PPP2R2A dephosphorylates FOXM1 (Rattus norvegicus)
PP2A-PPP2R2A dephosphorylates FOXM1 (Sus scrofa)
PP2A-PPP2R2A dephosphorylates FOXM1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2013-08-14)
Reviewed
Bruinsma, W  (2013-08-21)
Created
Orlic-Milacic, M  (2013-08-09)
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